肺炎合剂联合利奈唑胺治疗耐甲氧西林金黄色葡萄球菌肺炎的临床疗效及其对血清炎性因子水平的影响  

Clinical Effect of TCM Pneumonia Mixture Combined with Linezolid on MRSA-induced Pneumonia and the Impact on Serum Inflammatory Cytokines Levels

作　　者：谢小燕[1] 

机构地区：[1]四川省眉山市人民医院呼吸内科,620010

出　　处：《实用心脑肺血管病杂志》2017年第7期96-99,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的观察肺炎合剂联合利奈唑胺治疗耐甲氧西林金黄色葡萄球菌(MRSA)肺炎的临床疗效,并探讨其对血清炎性因子水平的影响。方法选取眉山市人民医院2014年2月—2016年11月收治的MRSA肺炎患者134例,采用随机数字表法分为对照组和研究组,每组67例。在常规对症治疗基础上,对照组患者给予利奈唑胺治疗,研究组患者给予肺炎合剂联合利奈唑胺治疗;两组均连续治疗2周。比较两组患者临床疗效、治疗前后中医症候积分、病菌清除率、血清肿瘤坏死因子α(TNF-α)和γ-干扰素(IFN-γ)水平,记录两组患者治疗期间不良反应发生情况。结果研究组患者临床疗效优于对照组(P<0.05)。治疗前两组患者中医症候积分比较,差异无统计学意义(P>0.05),治疗后研究组患者中医症候积分低于对照组(P<0.05)。研究组患者病菌清除率高于对照组(P<0.05)。治疗前两组患者血清TNF-α和IFN-γ水平比较,差异无统计学意义(P>0.05);治疗后研究组患者血清TNF-α和IFN-γ水平低于对照组(P<0.05)。两组患者治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论肺炎合剂联合利奈唑胺治疗MRSA肺炎的临床疗效确切,可有效改善患者临床症状,提高细菌清除率,降低血清炎性因子水平,且安全性较高。Objective To observe the clinical effect of TCM pneumonia mixture combined with linezolid on MRSA - induced pneumonia, to investigate the impact on serum inflammatory cytokines levels. Methods A total of 134 patients with MRSA - induced pneumonia were selected in the Peopled Hospital of Meishan from February 2014 to November 2016, and they were divided into control group and study group according to random number table, each of 67 cases. Based on conventional symptomatic treatment, patients of control group received linezolid, while patients of study group received TCM pneumonia mixture combined with linezolid; both groups continuously treated for 2 weeks. Clinical effect, TCM symptoms score before and after treatment, bacteria clearance rate, serum levels of TNF-α and IFN-γ before and after treatment were compared between the two groups, and incidence of adverse reactions was recorded during the treatment. Results Clinical effect of study group was statistically significantly better than that of control group （ P 〈 0. 05 ） . No statistically significant differences of TCM symptoms score was found between the two groups before treatment （ P 〉 0. 05 ） , while TCM symptoms score of study group was statistically significantly lower than that of control group after treatment （ P 〈 0. 05 ） . Bacteria clearance rate of study group was statistically significantly higher than that of control group （P 〈 0. 05 ） . No statistically significant differences of serum level of TNF-α or IFN-γ was found between the two groups before treatment （P 〉0. 05） , while serum levels of TNF-α and IFN-γ of study group were statistically significantly lower than those of control group （ P 〈 0. 05 ） . No statistically significant differences of incidence of adverse reactions was found between the two groups during the treatment （ P 〉 0. 05 ） . Conclusion TCM pneumonia mixture combined with linezolid has certain clinical eff

关 键 词：肺炎 耐甲氧西林金黄色葡萄球菌 抗炎剂(中药) 利奈唑胺 肿瘤坏死因子α Γ-干扰素 

分 类 号：R563.1[医药卫生—呼吸系统]