外周血降钙素原在支气管哮喘急性发作中应用价值探讨  

Application value of procalcitonin in peripheral blood in acute attack of bronchial asthma

作　　者：徐丽[1] 杜晓梅[1] 周敏[1] 肖春海[1] 苏朝霞 沈美珠[1] 曹睿杰 

机构地区：[1]上海市第六人民医院金山分院呼吸科,上海201599

出　　处：《临床肺科杂志》2017年第9期1581-1584,共4页Journal of Clinical Pulmonary Medicine

基　　金：金山区卫计委青年项目(No JSKJ-KTQN-2014-09);金山区卫生系统第五周期医学重点专科项目(编号:金卫医政(2016)6号)

摘　　要：目的探讨血清降钙素原(PCT)在支气管哮喘急性发作期中的应用价值。方法将我院在2015年01月至2016年3月呼吸科住院179例支气管哮喘急性发作期住院患者纳入研究,同时随机选取体检中心提供的200名健康成人体检者血清检测PCT水平作为正常对照组数据,判断支气管哮喘急性发作期中PCT的水平;之后依据PCT水平将179例患者分成PCT升高组及PCT正常组,分析两组患者的年龄、性别、病程、病情严重度等临床特点以及动态比较两组患者临床症状、血气分析、血白细胞计数及中性粒细胞比率、C反应蛋白(CRP)、Fe NO水平、肺通功能(FEV1及PEF)及抗生素应用情况等。结果 179例支气管哮喘急性发作期患者当日PCT(0d,0.19±0.18,ng/m L)与正常对照组PCT(0.13±0.11,ng/m L)水平比较有所升高,但差异无统计学意义(P>0.05);PCT升高组患者平均年龄大于PCT正常组,患者年龄、病情严重度、血白细胞总数、中性粒细胞比率、CRP水平及抗生素使用率均高于PCT正常组,肺通气功能(FEV1及PEF)低于PCT正常组,且差异有统计学意义(P<0.05)。结论 PCT在支气管哮喘急性发作严重度判断方面具有价值并可指导抗生素的应用。Objective To investigate the role of procalcitonin( PCT) in acute attack of bronchial asthma.Methods 179 patients with acute attack of asthma from January 2015 to March 2016 were selected as the study group,and 200 healthy people were taken as the control group. Their PCT levels were detected,and then the study group was subdivided into two groups based on PCT levels,the PCT elevated group and the PCT normal group. Their clinical features( such as age,sex,course and severity of the disease),symptoms,blood gas analysis,white blood cell count,neutrophil ratio,C-reactive protein( CRP),FeNO,FEV_1,PEF and antibiotics use were compared dynamically between the two sub-groups. Results PCT level was higher in the study group( 0. 19 ± 0. 18 ng/m L) than in the control group( 0. 13 ± 0. 11 ng/m L) on admission day( D0),but there was no statistical significance( P >0. 05). The average age was older in the PCT elevated group than in the PCT normal group. In addition,severity of the disease,white blood cell count,neutrophil ratio,C-reactive protein( CRP) and antibiotics use rate were all higher in the PCT elevated group than in the PCT normal group,but FEV_1 and PEF were lower( P < 0. 05). Conclusion PCT is valuable in judging the severity of acute exacerbations of asthma and can guide the use of antibiotics.

关 键 词：支气管哮喘 降钙素原 疾病严重程度 抗生素 

分 类 号：R562.25[医药卫生—呼吸系统]