非小细胞肺癌中红细胞分布宽度的临床研究  

Clinical research on red cell distribution width in non-small-cell lung cancer

作　　者：祝清清[1] 尤青海[1] 

机构地区：[1]安徽医科大学第一附属医院呼吸与危重症学科,安徽合肥230022

出　　处：《临床肺科杂志》2017年第9期1669-1671,共3页Journal of Clinical Pulmonary Medicine

基　　金：国家自然科学基金资助项目(No 81100053);国家临床重点专科建设项目基金(No 2012.649)

摘　　要：目的探讨红细胞分布宽度(RDW)与非小细胞肺癌(NSCLC)分期的关系。方法收集2016年我院212例新发NSCLC患者病例资料,采用回顾性研究,分析不同TNM分期间以及不同程度淋巴结、远处转移组间RDW的差异及相关性。结果Ⅰ期NSCLC的RDW水平与Ⅱ期患者无统计学差异(Z=-0.517,P=0.605),但Ⅰ期NSCLC的RDW水平低于Ⅲ期,差异有统计学意义(Z=-2.175,P=0.03),Ⅰ期NSCLC的RDW水平也明显低于Ⅳ期(Z=-3.233,P=0.001);而Ⅱ、Ⅲ、Ⅳ期间的RDW水平无显著统计学差异。无淋巴结转移的NSCLC(N0组)的RDW水平与仅存在同侧肺门、纵隔淋巴结转移组(N1和N2组)的RDW水平无统计学差异(Z=-1.213,P=0.225),但N0组的RDW水平明显低于存在对侧纵隔、肺门淋巴结和远处转移组(N3和远处转移组),差异有统计学意义(Z=-2.998,P=0.003),而N1、N2组和N3、远处转移组间的RDW水平无显著统计学差异(Z=-1.329,P=0.184)。NSCLC分期与RDW存在相关性(r=0.23,P=0.001),而且RDW与NSCLC不同程度淋巴结、远处转移间也存在相关性(r=0.205,P=0.003)。结论随着NSCLC肿瘤病灶的转移进展,RDW水平升高,且呈正相关,对NSCLC的转移有参考价值,但无法区别近端淋巴结转移和远处转移。Objective To investigate the significance of changes in the distribution width of red blood cells( RDW) in various stages of non-small cell lung cancer( NSCLC). Methods 212 cases of NSCLC were collected in2016. The differences and correlation in RDW were compared among different TNM stages,different levels of lymph nodes and distant metastases. Results The level of RDW had no statistical difference between stage Ⅰ and Ⅱ in NSCLC( Z =-0. 517,P = 0. 605),but it was lower at stage Ⅰ than at stage Ⅲ( Z =-2. 175,P = 0. 03) and stage Ⅳ( Z =-3. 233,P = 0. 001). There was no statistical difference among stage Ⅱ,Ⅲ and Ⅳ. The level of RDW had no statistical difference between the group without lymph node metastasis( N0) and the ipsilateral lung door group and the mediastinal lymph node metastasis group( group N1 and N2)( Z =-1. 213,P = 0. 225),but it was lower in the N0 group than in the contralateral mediastinum lymph node group and the distant metastasis group( N3 and the distant metastasis group)( Z =-2. 998,P = 0. 003). The level of RDW had no statistical difference among the N1,N2 and N3,distant metastasis groups( Z =-1. 329,P = 0. 184). The NSCLC staging was associated with RDW( r = 0. 23,P = 0. 001),and RDW was associated with different levels of nodes and distant metastases( r= 0. 205,P = 0. 003). Conclusion The level of RDW is positively correlated with NSCLC tumor lesion,which has a reference value for NSCLC transfer,but there is no difference between proximal node metastasis and distant metastasis.

关 键 词：非小细胞肺癌 红细胞分布宽度 临床研究 

分 类 号：R734.2[医药卫生—肿瘤]