维吾尔药木吒栓中石榴皮和石榴花水提取工艺的优化  

Optimization of the Water Extraction Technology of Punica granatum Peel and Flowers in Muzha Uighur Medicine Suppository

作　　者：田红林[1] 陈良[1] 孙芸[2] 李建梅 

机构地区：[1]新疆医科大学附属中医医院药学部,乌鲁木齐830012 [2]新疆医科大学中医学院中药系,乌鲁木齐830001 [3]新疆维吾尔自治区维吾尔医药研究所维吾尔医方剂学重点实验室,乌鲁木齐830049

出　　处：《中国药房》2017年第22期3099-3101,共3页China Pharmacy

基　　金：新疆维吾尔自治区中医民族医药科技人才培养项目(No.2016-03-05)

摘　　要：目的:优化维药木吒栓中石榴花与石榴皮的水提取工艺。方法:以总鞣质和鞣花酸含量为评价指标,以提取时间、提取次数和溶剂用量为考察因素,采用L_9(3~4)正交试验优化石榴花、石榴皮的水提取工艺并进行验证试验。结果:石榴花与石榴皮中总鞣质和鞣花酸的最优提取工艺为将2味药材用10倍量水回流提取3次,每次0.5 h;验证试验中3批药材提取出的总鞣质与鞣花酸平均含量分别为151.69、24.59 mg/g(RSD分别为1.15%、1.41%,n=3)。结论:优化的提取工艺稳定、可行,可用于木吒栓中石榴花、石榴皮中总鞣质和鞣花酸的提取。OBJECTIVE：To optimize the water extraction technology of Punica granatum peel and flowers in Muzha suppository. METHODS：Using total tannin,ellagic acid contents as evaluation indexes,extration time,times,the amount of solvents as investigation factors,L9（3^4）orthogonal test was adopted to optimize the water extraction technology of P. granatum flowers and peel.And verification test was conducted. RESULTS：The optimal extraction technology of total tannin and ellagic acid in P. granatum peel and flowers was as follow as 10-fold water reflux extraction for 3 times with 2 herbs,0.5 h every time. The average content of total tannin and ellagic acid extracted from 3 batches of herbs was 151.69 mg/g（RSD=1.15%,n=3）,24.59 mg/g（RSD=1.41%,n=3）in the verification test,respectively. CONCLUSIONS：The optimized extraction technology is stable,feasible,and can be used for extracting the total tannin and ellagic acid in P. granatum peel and flowers.

关 键 词：木吒栓 石榴花 石榴皮 提取工艺 正交试验 总鞣质 鞣花酸 

分 类 号：R284.2[医药卫生—中药学]