基于表面自由能的粒子设计研究进展  

Recent Progress of Particle Design Engineering Based on Surface Free Energy

作　　者：明良山[1] 李哲[1,2] 吴飞[1,2] 杜若飞[1] 冯怡[1] MING Liang-shan LI Zhe WU Fei DU Ruo-fei FENG Yi(Engineering Research Center of Modern Prepa- ration of TCM, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China)

机构地区：[1]上海中医药大学中药现代制剂技术教育部工程研究中心,上海201203 [2]上海中医药大学中药学院,上海201203

出　　处：《中国药学杂志》2017年第14期1201-1207,共7页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(81403110);上海市科委资助项目(15DZ2292000)

摘　　要：随着对表面自由能研究的深入,利用粒子设计过程表面自由能相关参数的变化,探索出许多基于表面自由能性质的粒子设计系统。物料经粒子设计后改变理化属性,表面自由能产生了新的变化。因此,可通过表面自由能性质变化特征指导粒子设计过程。笔者综述了表面自由能性质在微粉化、粒子改性、混合、包衣、制丸与制粒等粒子设计过程的应用。通过表面自由能相关参数构建了色散力-极性力模型和黏附-凝聚模型,并阐述了色散力-极性力模型和黏附-凝聚模型在粒子设计中的应用。Presently interests are growing in the field of surface free energy （SFE）. With the further research, more particle design engineering based on SFE are summarized via characterizing the related properties of SFE during the process of particle design. SFE of materials will vary with changing the physical properties of particles via modifying the surface of particles with particle design. In this study, we summarized the application of SFE in powder micronization, particle modification, mixing, coating, pelletilization and granu- lation, etc. Dispersive-polar model and adhesion-cohesion model were established based on the parameters of SFE. The application of the two models were also illustrated in the particle design engineering.

关 键 词：表面自由能 粒子设计 色散力-极性力模型 黏附-凝聚模型 铺展系数 

分 类 号：R944[医药卫生—药剂学]