2016年广东省寨卡病毒感染者临床特征和病原学结果分析  

Clinical characteristics of pathogenic detection of Zika virus infected cases in Guangdong,2016

作　　者：张萌[1] 贾海梅[2,3] 杨治文 陈茂余[5] 李剑森[1] 叶新[6] 管大伟[1] 岑小莉 黄国[5] 冯绮雯 倪锡河[7] 钟豪杰[1] 宋铁[1] ZHANG Meng JIA Hai - mei YANG Zhi - wen CHEN Mao - yu LI Jian - sen YE Xin GUAN Da - wei CEN Xiao - li HUANG Guo FENG Qi - wen NI Xi - he ZHONG Hao - jie SONG Tie(Guangdong provincial center for disease control and prevention, Guangzhou, Guangdong 511430, China)

机构地区：[1]广东省疾病预防控制中心,广东广州511430 [2]中国现场流行病学培训项目,北京102206 [3]福州市疾病预防控制中心,福建福州350004 [4]恩平市疾病预防控制中心,广东江门529400 [5]江门市疾病预防控制中心,广东江门529030 [6]广州市天河区疾病预防控制中心,广东广州510655 [7]珠海市疾病预防控制中心,广东珠海519060

出　　处：《现代预防医学》2017年第15期2857-2860,共4页Modern Preventive Medicine

摘　　要：目的了解寨卡病毒病的临床特点及感染者病原学检测结果,为我国寨卡病毒病防控工作提供科学依据。方法分析2016年广东省11例病例的临床特点及11例病例和3例隐性感染者标本检测结果。结果 11例病例均发生皮疹,6例眼结膜充血,4例咽部充血,2例发热(体温>37.3℃),均无肌肉关节痛表现;9例病例以皮疹、2例以发热为首发症状。皮疹持续2-8天,中位数6天,发生部位以胸部和背部为最多,成人与儿童的皮疹形态不同。病原学检测,血清PCR阳性占45.45%(5/11),唾液阳性占90.91%(10/11),尿液阳性为100%(11/11);隐性感染者中,血清检测阳性1例,唾液阳性1例,尿液阳性3例。结论寨卡病毒病症状较轻,早期发现较困难;建议采用血液、唾液、尿液同时开展核酸检测并作为诊断依据,同时在伊蚊活跃期常态下做好蚊媒密度控制工作,降低本地传播风险。Objective To provide scientific evidence for prevention and control of Zika virus diseases in China. Methods The clinical characteristics of 11 cases, specimen detection results of 11 cases and 3 latent infected patients were analyzed. Results Theoretically the incubation of 11 cases was predicted as 1 to 9 days, with median 4 days. The result showed that 11 cases performed rash, following 6 cases performed eonjunctival congestion and 4 cases performed pharyngeal hyperemia. Whereas only 2 cases performed fever （body temperature 〉 37.3℃ ） ,without muscle pain or arthralgia. Rash was the first symptom of 9 cases, while 2 cases performed fever as their first sign of Zika. The symptom of rash lasted about 2 to 8 days, with median 6 days. The onset of symptom was mainly on chest and backside. The state of rash showed a significant difference between adults and children. Among all specimens of 11 cases, the positive detection rate was 45.45% （5/11） in serum,90.91% （ 10/11 ） in saliva and 100% （11/11 ） in urine. Moreover,there was 1 latent case detected positive in serum and saliva respectively, and 3 latent cases were detected positive in urine. Conclusion Symptom onset of Zika is mild ,which impacts the early diagnosis. We suggest using nucleic acid detection on serum, salvia and urine as diagnosis basis. Besides, vector density control should be well conducted for reducing the risks of local transmissions of Zika.

关 键 词：寨卡病毒病 临床特征 隐性感染者 皮疹 带毒时间 

分 类 号：R181.23[医药卫生—流行病学]