过山蕨水提物的化学成分  

Chemical constituents of the water extract from Camptosorus sibiricus Rupr.

作　　者：梁大连 于亮 李宁[2] 刘玉黔 郭琪 王芳 LIANG Da-lian YU Liang LINing LIU Yu-qian GUO Qi WANG Fang(Shandong Academy of Pharmaceutical Sciences, Shandong Key Laboratory of Chemical Medicines, Ji＇ nan 250101, China School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University, Shenyang 110016, China)

机构地区：[1]山东省药学科学院,山东省化学药物重点实验室,山东济南250101 [2]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2017年第7期541-545,552,共6页Journal of Shenyang Pharmaceutical University

基　　金：国家重大新药创制项目(2010ZX09401302-002-015);山东省重点研发计划项目(2016GSF202006)

摘　　要：目的研究过山蕨(Camptosorus sibiricus Rupr.)水提物的化学成分。方法通过正相硅胶、MCI树脂、Sephadex LH-20、制备薄层色谱和反相HPLC等多种色谱技术,对过山蕨水煎煮提取物的化学成分进行分离纯化,通过波谱数据分析,鉴定了化合物的结构。结果共分离得到9个化合物,分别鉴定为:苄醇-O-β-D-吡喃葡萄糖苷(1)、3,5-二甲氧基-4-羟基-苯甲酰基-O-β-D-吡喃葡萄糖酯(2)、4-羟基-3-甲氧苯基-O-β-D-吡喃葡萄糖苷(3)、3,5-二甲氧基-4-羟基苯基-O-β-D-吡喃葡萄糖苷(4)、4-(2-羟乙基)-2-甲氧苯基-O-β-D-吡喃葡萄糖苷(5)、银桦苷G(6)、2-(4-羟苯基)乙基-O-β-D-吡喃葡萄糖苷(7)、2-(3,4-二羟基苯基)乙基-O-β-D-吡喃葡萄糖苷(8)、2-羟基-5-(2-羟乙基)-苯基-O-β-D-吡喃葡萄糖苷(9)。结论化合物1-9均为从过山蕨属中首次分离得到。Objective To investigate the chemical constituents of the water extract from Camptosorus sibiricus Rupr. Methods Compounds were isolated by a combination of various chromatographic techniques including silica gel column chromatography,sephadex LH-20 column chromatography and reversed-phase HPLC. Their structure was elucidated on the basis of their physicochemical properties and spectral data.Results Nine compounds were identified as benzyl alcohol-O-β-D-glucoside（ 1）,3,5-dimethoxy-4-hydroxybenzoylO-β-D-glucopyranosyl ester（ 2）,tachioside（ 3）,3,5-dimethoxy-4-hydroxyphenyl-O-β-Dglucopyranoside（4）,4-（ 2-hydroxyethyl）-2-methoxyphenyl-O-β-D-glucopyranoside（ 5）,g revilloside G（ 6）,2-（ 4-hydroxyphenyl） ethyl-O-β-D-glucopyranoside（ 7）, 2-（ 3, 4-dihydroxyphenyl） ethyl-O-β-Dglucopyranoside（8）,and 2-hydroxy-5-（ 2-hydroxyethyl）-phenyl-O-β-D-glucopyranoside（ 9）, respectively.Conclusions Compounds 1-9 are isolated from the Camptosorus for the first time.

关 键 词：过山蕨 过山蕨属 水提物 苯乙醇苷 

分 类 号：R932[医药卫生—生药学]