血必净联合胸腺五肽辅助抗生素治疗老年重症肺炎对免疫功能及炎症因子的影响  

Effect on immune function and inflammatory factors of adjuvant antibiotic therapy through Xuebijing combined with thymopentin in elderly patients with severe pneumonia

作　　者：蒋一雅[1] 仇铁峰[1] 庄志方[1] 

机构地区：[1]常州市武进人民医院呼吸内科,江苏常州213000

出　　处：《海南医学院学报》2017年第11期1471-1473,1477,共4页Journal of Hainan Medical University

基　　金：江苏省科技支撑计划(BC2015271)~~

摘　　要：目的:探讨血必净联合胸腺五肽辅助抗生素治疗老年重症肺炎对免疫功能及炎症因子的影响。方法:选择老年重症肺炎患者100例,根据入组序列号奇偶数分为观察组与对照组,每组50例,其中对照组给予机械通气、退热、祛痰、抗感染等常规重症肺炎治疗,同期给予血必净静脉滴注;观察组在常规治疗的基础上采取血必净联合胸腺五肽静脉滴注治疗,比较两组治疗前、治疗7、14dT淋巴细胞亚群水平及血清炎症因子CRP、IL-6、IL-1、TNF-α水平。结果:两组不同时间点CD3^+、CD4^+、CD8^+、CD4^+/CD8^+水平差异有统计学意义(P<0.05),其中CD3^+、CD4^+、CD4^+/CD8^+水平:T2>T1>T0,CD8^+水平:T2<T1<T0;观察组的CD3^+、CD4^+、CD4^+/CD8^+水平升高幅度、CD8^+水平下降幅度大于对照组,差异有统计学意义(P<0.05);两组不同时间点血清CRP、IL-6、IL-1、TNF-α水平差异有统计学意义(P<0.05),血清CRP、IL-6、IL-1、TNF-α水平均T2<T1<T0,呈下降趋势;观察组的血清CRP、IL-6、IL-1、TNF-α水平下降幅度显著大于对照组,差异有统计学意义(P<0.05)。结论:血必净联合胸腺五肽辅助抗生素治疗老年重症肺炎有助于改善机体免疫功能,调低炎症因子水平。Objective：To investigate the effect on immune function and inflammatory factors of adjuvant antibiotic therapy through Xuebijing combined with thymopentin in elderly patients with severe pneumonia.Methods：Divided 100 cases of elderly patients with severe pneumonia into the observation group and the treatment group according to odevity of serial number with fifty patients in each group.Gave control group severe pneumonia conventional treatment,such as mechanical ventilation,antifebrile,removing phlegm and anti-infection,and gave Xuebijing by intravenous drop simultaneously;observation group was given Xuebijing combined with thymopentin by intravenous drop on the base of conventional treatment.Then compared the T lymphocyte subpopulation and serum inflammatory factors level including CRP,IL-6,IL-1and TNF-αof two groups before treatment and 7d,14 dof treatment respectively.Results：There was significant difference in the level of CD3^＋,CD4^＋,CD8^＋,CD4^＋/CD8^＋in this two groups at different time points（P〈0.05）,and that the level of CD3^＋,CD4^＋,CD4^＋/CD8^＋：T2〉T1〉T0,CD8^＋level：T2〈T1〈T0;The increasing range of CD3^＋,CD4^＋,CD4^＋/CD8^＋level and the decreasing range of CD8^＋in the observation group were larger than that in the control group,there was statistical significant difference（P〈0.05）.The level of serum inflammatory factors CRP,IL-6,IL-1,TNF-αin two groups at different time points were statistical significant difference（P〈0.05）,all the CRP,IL-6,IL-1and TNF-αlevel were T2T1T0,presenting a downward trend;The descending range of serum CRP,IL-6,IL-1,TNF-αlevel in the observation was larger compared with the control group,there was significant difference（P〈0.05）.Conclusions：The adjuvant antibiotic therapy through Xuebijing combined with thymopentin in elderly patients with severe pneumonia could improve the immune function and lower the inflammatory factors level.

关 键 词：老年重症肺炎 血必净 胸腺五肽 免疫功能 炎症因子 

分 类 号：R563.1[医药卫生—呼吸系统]