血清S1P、Adropin水平对脑血管支架植入术后再狭窄的预测价值及其与血管活性物质、细胞因子的关系  

Predictive value of serum S1P and Adropin levels for the restenosis after cerebrovascular stent implantation and their relationship with vasoactive substances and cytokines

作　　者：王力[1] 李志国[1] 刘艳[1] 代高英[2] 许萍[3] 

机构地区：[1]四川省自贡市第三人民医院神经内科,四川自贡643020 [2]四川省自贡市第三人民医院急诊科,四川自贡643020 [3]四川省自贡市第三人民医院检验科,四川自贡643020

出　　处：《海南医学院学报》2017年第11期1516-1519,共4页Journal of Hainan Medical University

基　　金：四川省卫生厅科研项目(150743)~~

摘　　要：目的:探讨血清S1P、Adropin水平对脑血管支架植入术后再狭窄的预测价值及其与血管活性物质、细胞因子的关系。方法:选取在本院接受脑血管支架植入术治疗的脑梗死患者109例,回顾其治疗结局并将脑血管支架植入术后再狭窄患者35例作为观察组、脑血管支架植入术后未狭窄患者74例作为对照组。对比两组支架植入前后血清中S1P、Adropin的水平,进一步探讨S1P、Adropin水平与脑血管支架植入术后再狭窄患者血管活性物质、细胞因子水平的内在联系。结果:支架植入前,两组血清中S1P、Adropin水平,血管活性物质、细胞因子水平的差异无统计学意义(P>0.05)。支架植入后,观察组血清中S1P、Adropin的水平低于对照组;血清中血管活性物质NO的水平低于对照组,ET-1、TXB2、AngⅡ的水平高于对照组;血清中炎症因子TNF-α、IL-6、IL-10、IL-13的水平高于对照组(P<0.05)。经Pearson检验发现,脑血管支架植入术后再狭窄患者血清S1P、Adropin水平与血管活性物质、细胞因子水平呈直接相关关系。结论:脑血管支架植入术后再狭窄患者存在血清S1P、Adropin低表达,且其具体表达量与血管活性物质、炎症因子水平直接相关,可作为脑血管支架植入术后再狭窄早期预测的可靠指标。Objective：To explore the predictive value of serum S1 Pand Adropin levels for the restenosis after cerebrovascular stent implantation and their relationship with vasoactive substances and cytokines.Methods：A total of 109 patients with cerebral infarction who accepted cerebrovascular stent implantation in our hospital between July 2012 and May 2016 were selected,their treatment outcome were reviewed,35 patients with restenosis after cerebrovascular stent implantation were selected as observation group,and 74 patients without restenosis after cerebrovascular stent implantation were selected as control group.Serum S1 Pand Adropin levels were compared between two groups of patients before and after stent implantation,and the inner link of S1 Pand Adropin levels with vasoactive substance and cytokine levels in patients with restenosis after cerebrovascular stent implantation was further explored.Results：Before stent implantation,the differences in serum levels of S1 P,Adropin,vasoactive substances and cytokines were not statistically significant between two groups of patients（P〉0.05）.After stent implantation,serum S1 Pand Adropin levels in observation group were lower than those in control group;serum vasoactive substance NO level was lower than that in control group while ET-1,TXB2 and AngⅡlevels were higher than those in control group;serum inflammatory factors TNF-α,IL-6,IL-10 and IL-13 levels were higher than those in control group（P〈0.05）.Pearson test showed that serum S1 Pand Adropin levels in patients with restenosis after cerebrovascular stent implantation were directly correlated with the levels of vasoactive substances and cytokines.Conclusions：Serum S1 Pand Adropin are lowly expressed in patients with restenosis after cerebrovascular stent implantation,and their specific expression are directly correlated with the levels of vasoactive substances and inflammatory cytokines,and can be used as the reliable indexes for early prediction of restenosis after cerebrovascular stent implantatio

关 键 词：脑血管支架植入术 S1P Adropin 血管活性物质 

分 类 号：R318[医药卫生—生物医学工程]