PECAM-1基因C373G位点多态性与子痫前期患者内皮损伤、胎盘病理损伤的相关性  

Correlation of PECAM-1 gene C373G locus polymorphism with endothelial injury and placental pathological damage in patients with preeclampsia

作　　者：严梅[1] 伍班名 曾丽[1] 

机构地区：[1]宜宾市第二人民医院产科,四川宜宾644000 [2]宜宾市第三人民医院急诊科,四川宜宾644000

出　　处：《海南医学院学报》2017年第11期1537-1540,共4页Journal of Hainan Medical University

基　　金：四川省卫生厅科学研究项目(101021)~~

摘　　要：目的:研究PECAM-1基因C373G位点多态性与子痫前期患者内皮损伤、胎盘病理损伤的相关性。方法:选择在宜宾市第二人民医院产科分娩的子痫前期孕妇和健康孕妇,分别作为PE组和对照组。采集外周血后测定PECAM-1基因C373G位点的多态性以及内皮损伤分子sFlt-1、sEng、PAR-1、ET-1的含量;采集胎盘组织并测定病理损伤分子Gadd45α、TIMP2、Fas、Apaf-1、caspase-3的含量。结果:PE组孕妇外周血中PECAM-1基因C373G位点GC和GG基因型的构成比、等位基因G的构成比显著高于对照组,CC基因型的构成比、等位基因C的构成比显著低于对照组;PE组患者血清中sFlt-1、sEng、PAR-1、ET-1的含量以及胎盘中Gadd45α、TIMP2、Fas、Apaf-1、caspase-3的含量显著高于对照组;PECAM-1基因C373G位点GC和GG基因型PE孕妇血清中sFlt-1、sEng、PAR-1、ET-1的含量以及胎盘中Gadd45α、TIMP2、Fas、Apaf-1、caspase-3的含量显著高于CC基因型PE孕妇。结论:PECAM-1基因C373G位点等位基因G的增多与子痫前期患者内皮损伤、胎盘病理损伤密切相关。Objective：To study the correlation of PECAM-1gene C373 Glocus polymorphism with endothelial injury and placental pathological damage in patients with preeclampsia.Methods：Pregnant women with preeclampsia and healthy pregnant women delivering in Obstetrics Department of Yibin Second People＇s Hospital between May 2014 and September2016were selected and enrolled in PE group and control group respectively.Peripheral blood was collected to determine PECAM-1gene C373 Gpolymorphism as well as the contents of endothelial injury molecules sEng,PAR-1,sFlt-1and ET-1;placenta tissue was collected to determine the contents of pathological damage molecules Gadd45α,TIMP2,Fas,Apaf-1and caspase-3.Results：PECAM-1gene C373 Glocus GC and GG genotype constituent ratio and allele G constituent ratio in peripheral blood of PE group were significantly higher than those of control group while CC genotype constituent ratio and allele C constituent ratio were significantly lower than those of control group.sFlt-1,sEng,PAR-1and ET-1contents in serum as well as Gadd45α,TIMP2,Fas,Apaf-1and caspase-3contents in placenta of PE group were significantly higher than those of control group;sFlt-1,sEng,PAR-1and ET-1contents in serum as well as Gadd45α,TIMP2,Fas,Apaf-1and caspase-3contents in placenta of PE patients with PECAM-1gene C373 Glocus GC and GG genotypes were higher than those of PE patients with CC genotype.Conclusion：Increased allele G in PECAM-1gene C373 Gloci is closely correlated with endothelial injury and placental pathological damage in patients with preeclampsia.

关 键 词：子痫前期 血小板内皮细胞粘附分子-1 基因多态性 内皮损伤 

分 类 号：R714.245[医药卫生—妇产科学]