丹参饮对化疗后气阴两虚型膀胱癌患者胃肠道抑制及免疫功能的影响  

Effect of Danshenyin on Gastrointestinal Inhibition and Immune Index of Patients with Bladder Cancer After Chemotherapy

作　　者：蒋远斌[1] 王铀[1] 郭宇[1] 刘煜[1] 王曦[1] 杨兴智[1] JIANG Yuan-bin WANG You GUO Yu LIU Yu WANG Xi YANG Xing-zhi(Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021, China)

机构地区：[1]重庆市中医院,重庆400021

出　　处：《中国实验方剂学杂志》2017年第15期191-195,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：重庆市卫生局中医药科研项目(ZY20132161)

摘　　要：目的:探讨丹参饮对膀胱癌患者化疗后胃肠道抑制及免疫功能的影响,并探讨其作用机制。方法:将重庆市中医院收治的膀胱癌患者140例均行化疗治疗,随机抽取70例于化疗期间服用丹参饮(观察组),其余70例为对照组。比较两组胃肠道抑制比例,化疗前后细胞免疫和体液免疫指标水平、自然杀伤(natural killer,NK)细胞水平及血清相关因子水平。结果:化疗后24 h内,对照组Ⅲ~Ⅳ比例高于观察组(P<0.05),对照组0级比例低于观察组(P<0.05)。在72 h内,观察组0级比例高于对照组(P<0.05),Ⅰ~Ⅱ和Ⅲ~Ⅳ比例均低于对照组(P<0.05)。化疗后,两组患者CD3^+,CD4^+和CD4^+/CD8^+均较化疗前降低(P<0.05),CD8^+水平均较化疗前升高(P<0.05);观察组CD3^+,CD4^+和CD4^+/CD8^+的变化程度均小于对照组(P<0.05)。化疗后,两组患者免疫球蛋白A(immunoglobulin A,IgA)和免疫球蛋白M(immunoglobulin M,IgM)水平均较化疗前降低(P<0.05)。化疗后,两组患者NK细胞水平均低于化疗前(P<0.05),观察组下降幅度小于对照组(P<0.05)。化疗后,观察组的白细胞介素-12(interleukin-12,IL-12)和肿瘤坏死因子(tumor necrosis factor,TNF)-α水平低于对照组(P<0.05)。结论:在化疗时,加服丹参饮可有效降低患者的胃肠道抑制,并更好的调节患者免疫功能。Objective：To analyze the effect of Danshenyin on gastrointestinal inhibition and immune index of patients with bladder cancer after chemotherapy and its action mechanism.Method：A total of 140 patients with bladder cancer were included in the study.All of the patients received chemotherapy.Among them,70 patients were selected to take Danshenyin during chemotherapy（observation group）,while the remaining patients were control group.Proportion of gastrointestinal inhibition,cellular immunity,humoral immunity,natural killer（NK） and serum-related factor level were compared before and after chemotherapy.Result：Within 24 hours after chemotherapy,the proportion of Ⅲ-Ⅳ of control group were higher than that of observation group（P〈0.05）.The proportion of level 0 of control group was lower than that of observation group（P〈0.05）.Within 72 hours after chemotherapy,the proportion of level 0 of observation group was still higher than that of control group,and the proportions of Ⅰ-Ⅱ and Ⅲ-Ⅳ were lower than those of the control group.After chemotherapy,CD3~＋,CD4~＋ and CD4~＋/CD8~＋ levels of two groups were lower than those before chemotherapy（P〈0.05）.CD8~＋ level was higher than that before chemotherapy（P〈0.05）.CD3~＋,CD4~＋ and CD4~＋/CD8~＋ levels of observation group were better than those of control group（P〈0.05）.After chemotherapy,immunoglobulin A（IgA） and immunoglobulin M（IgM） levels of two groups were lower than those before chemotherapy（P〈0.05）.After chemotherapy,NK level of two groups was lower than that before chemotherapy（P〈0.05）.The observation group decreased less than control group（P〈0.05）.Interleukin-12（IL-12） and tumor necrosis factor-α（TNF-α） levels of the observation group were lower than those of control group（P〈0.05）.Conclusion：During chemotherapy,Danshenyin can effectively reduce gastrointestinal inhibition and adjust immune function.

关 键 词：丹参饮 化疗 膀胱癌 胃肠道抑制 免疫功能 

分 类 号：R287[医药卫生—中药学] R737.14[医药卫生—中医学]