Association between Plasma Metal Levels and Diabetes Risk： a Case-control Study in China  

作　　者：LI Xiu Ting YU Peng Fei GAO Yan GUO Wen Hui WANG Jun LIU Xin GU Ai Hua JI Gui Xiang DONG Qiu WANG Bo Shen CAO Ying ZHU Bao Li XIAO Hang 

机构地区：[1]Nanjing Prevention and Treatment Genter for Occupational Disease, Nanjing 210042, Jiangsu, China [2]Key Lab of Modern Toxicology, Ministry of Education, Department of Toxicology, School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China [3]Suzhou Municipal Center for Disease Prevention and Control, Suzhou 215003, Jiangsu, China [4]School of Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, China [5]Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210028, Jiangsu, China [6]Ministry of Environmental Protection, Nanjing Institute of Environmental Sciences, Nanjing 210042, Jiangsu, China [7]Department of ENT, Huai 'an Second People 's Hospital, Huai 'an 211700, Jiangsu, China

出　　处：《Biomedical and Environmental Sciences》2017年第7期482-491,共10页生物医学与环境科学（英文版）

基　　金：supported by Jiangsu Provincial Medical Youth Talent(QNRC2016127);Medical Science and Technology Development Foundation,Nanjing Department of Health(YKK14169);Jiangsu Provincial Medical Innovation Team(CXTDA2017029);National Natural Science Foundation of China(81602919)

摘　　要：Objective Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population. Methods We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province. A total of 122 newly diagnosed cases of type 2 diabetes and 429 matched controls were recruited from community physical examinations in Suzhou City of Jiangsu Province. Plasma metal levels were measured by inductively-coupled plasma mass spectrometry. Results After adjusting for confounders, plasma vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were associated with diabetes risk （P 〈 0.05）. The adjusted OR increased with increasing concentration of vanadium, manganese, copper, zinc, and cesium. Conclusion Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes. Monitoring of environmental metal levels and further studies are urgently needed.Objective Many metals, some of which have been classified as environmental endocrine disruptors, are used extensively in everyday consumer products and are ubiquitous in our living environment. In the present study, we aimed to explore the associations between the prevalence risk of type 2 diabetes and plasma levels of 20 trace elements as well as those of heavy metals in a Han Chinese population. Methods We conducted a case-control study to investigate the associations between plasma concentrations of 20 metals and diabetes in Jiangsu province. A total of 122 newly diagnosed cases of type 2 diabetes and 429 matched controls were recruited from community physical examinations in Suzhou City of Jiangsu Province. Plasma metal levels were measured by inductively-coupled plasma mass spectrometry. Results After adjusting for confounders, plasma vanadium, chromium, manganese, copper, zinc, arsenic, selenium, strontium, palladium, cadmium, cesium, and barium were associated with diabetes risk （P 〈 0.05）. The adjusted OR increased with increasing concentration of vanadium, manganese, copper, zinc, and cesium. Conclusion Many metals, including manganese, copper, zinc, arsenic, selenium, and cadmium in plasma, are associated with the morbidity of diabetes. Monitoring of environmental metal levels and further studies are urgently needed.

关 键 词：Metals DIABETES CHROMIUM ARSENIC CADMIUM 

分 类 号：R587.1[医药卫生—内分泌]