人感染H7N9禽流感重症6例临床特征分析  

Clinical characteristics of 6 severe cases of human infections with avian influenza A(H7N9)

作　　者：李毅[1] 赵川[1] 何正光[1] 骆华宇 敬毅[1] 曹霖[1] 夏洪涛[1] 龚宇[1] 刘涛[2] 何洋[3] 

机构地区：[1]遂宁市人感染H7N9禽流感救治专家组遂宁市中心医院,四川遂宁629000 [2]遂宁市人感染H7N9禽流感救治专家组遂宁市中医院,四川遂宁629000 [3]遂宁市人感染H7N9禽流感救治专家组遂宁市第一人民医院,四川遂宁629000

出　　处：《西部医学》2017年第8期1110-1114,共5页Medical Journal of West China

基　　金：四川省卫生计生委科研项目(150244)

摘　　要：目的总结四川省首发6例人感染H7N9重症禽流感患者的临床特点,为禽流感疫情的防控及诊治提供借鉴。方法回顾性分析四川省遂宁市收治的6例人感染H7N9重症禽流感患者临床资料。结果 6例患者均有发热、咳嗽、呼吸困难等症状,均有流行病学史,院外治疗时间长,所有病人均未在48小时内使用抗病毒药。治疗上予机械通气、抗病毒、抗感染等综合治疗。6例患者均已2次复查咽拭子阴性,其中1例患者康复出院,3例患者死亡,另2例患者目前仍在积极治疗中。结论对人感染H7N9禽流感提高认识,对重点人群进行早期筛查,及时诊断、早期治疗是降低人感染H7N9禽流感病死率的关键。Objective To summarize the clinical data and find the characteristics of the first 6 severe cases of hu man infections with avian influenza A （H7N9） in Sichuan Province, so as to help the prevention and control of epidemic situation with avian influenza and improve the level of diagnosis and treatment of the disease. Methods Clinical data were collected and analyzed retrospectively from 6 patients with confirmed human infections with avian influenza A （H7N9）. Results The symptoms in common of the 6 cases were high fever, cough and dyspnea. A contact history with living poultry and a long time treatment outside the hospital were found. Thus antiviral drugs were taken more than 48 hours after onset. During hospitalization, a comprehensive treatment was received by all the cases, such as mechanical ventila- tion, anti-virus, anti infection. All of them turned negative with viral nucleic acid after treatment （two consecutive tes- ting）, of which one case was discharged with rehabilitation, three cases died, and the other two cases were still in the hospital. Conclusion Early screening for key population, early diagnosis and treatment are the key points to reduce the mortality of human infections with avian influenza A （H7N9）.

关 键 词：人感染H7N9禽流感 重症病例 临床特征 

分 类 号：R373.1[医药卫生—病原生物学]