尿毒症患者不宁腿综合征研究进展  

Advances of uremic restless legs syndrome

作　　者：杜亭[1] 夏运风[1] 陈泽君[1] 甘华[1] 

机构地区：[1]重庆医科大学附属第一医院肾脏内科,重庆400016

出　　处：《西部医学》2017年第8期1180-1184,共5页Medical Journal of West China

摘　　要：不宁腿综合征(Restless legs syndrome,RLS)是终末期肾病(End stage renal disease,ERSD)患者常见的神经系统并发症,主要表现为夜间或者休息时出现肢体异常感觉,活动后症状可缓解,严重影响了患者的睡眠和生活质量,缩短了患者生存时间。该病发病机制不甚明确,可能与遗传基因、多巴胺能神经系统功能紊乱、铁缺乏或代谢异常、贫血、尿毒症毒素等有关,目前诊断主要依据患者病史及临床症状,治疗方面包括非药物治疗和药物治疗。本文就尿毒症患者不宁腿综合征的流行病学、发病机制、诊断、治疗等的研究进展做一综述。Restless legs syndrome is highly prevalent in end stage renal disease patients. The symptoms of RLS typically occur during inactivity and frequently interfere with sleep, it is characterized by an urge to move the legs that is often hard to resist and is usually associated with disagreeable leg sensations. The pathogenesis of the disorder is still un clear, but it is widely accepted that it involves family history, disruption of dopaminergic functions, lack of iron and ure mic toxin and so on. Restless legs syndrome is best diagnosed by an experienced clinician. The treatment of restless legs syndrome involves various pharmacologic approaches and nonpharmacologic approaches. In this article, we review the di agnosis, epidemiologic feature and treatment of end stage renal disease patients with the restless legs syndrome.

关 键 词：不宁腿综合征 终末期肾病 发病机制 治疗 

分 类 号：R692.5[医药卫生—泌尿科学] R746.9[医药卫生—外科学]