炎症反应在ARDS中的作用机制研究进展  

Research advances of the role of inflammatory responses in ARDS

作　　者：何流漾[1,2] 郑建洲[1,2] 夏蕾[1] 戚春建[2] 王勇[1] 杨明夏[1,3] 

机构地区：[1]南京医科大学附属常州市第二人民医院心肺血管研究所,江苏常州213000 [2]南京医科大学附属常州市第二人民医院中心实验室,江苏常州213000 [3]南京医科大学附属常州市第二人民医院呼吸与危重症医学科,江苏常州213000

出　　处：《中华危重病急救医学》2017年第7期651-655,共5页Chinese Critical Care Medicine

基　　金：国家自然科学基金（81472199）;江苏省自然科学基金（BK20141162）

摘　　要：急性肺损伤/急性呼吸窘迫综合征（ALI/ARDS）是由多种因素诱导的大面积炎症性肺损伤,目前缺乏有效的治疗方案,病死率居高不下.近年来对该病研究的不断深入,肯定了炎症反应在ALI/ARDS发生发展过程中的关键性作用.本文从炎症角度出发,依次从发病机制、炎症相关信号通路等方面阐述治疗ALI/ARDS的可行性方案,为临床诊治提供新思路.Acute lung injury/acute respiratory distress syndrome （ALI/ARDS） is an inflammatory lung injury induced by a variety of factors, and these diseases are associated with high rates of mortality due to the lack of effective treatments. Based on the latest research in ALI/ARDS, it is widely accepted that generalized inflammatory responses play a critical role in initiating and developing process of ALI/ARDS. We make a brief review on the immune-pathogenesis and the signaling pathways of ALI/ARDS from the perspective of inflammation, thereby helping develop novel therapeutic strategy for treatment of patients with ALI/ARDS.

关 键 词：肺损伤 急性 呼吸窘迫综合征 急性 炎症 细胞因子 

分 类 号：R563.8[医药卫生—呼吸系统]