CRRT对脓毒症治疗中抗菌药物清除作用的影响  

Effect of CRRT on the clearance of antibiotics in the treatment of sepsis

作　　者：宗景景 刘春生 付晓菲 周静超 王丹 

机构地区：[1]解放军火箭军总医院药学部,北京100088 [2]解放军火箭军总医院骨科,北京100088

出　　处：《中华危重病急救医学》2017年第7期662-665,共4页Chinese Critical Care Medicine

基　　金：国家自然科学基金青年科学基金（81301662）;北京市科技新星计划（Z161100004916165）

摘　　要：脓毒症是指宿主对感染产生失控反应,出现危及生命的器官功能障碍的临床综合征,连续性肾脏替代治疗（CRRT）是目前临床治疗脓毒症的方式之一.对于接受CRRT的患者,合理的抗菌药物治疗对患者感染的控制至关重要.然而,目前针对CRRT时抗菌药物的剂量调整尚没有明确的指导方案.通过分析国内外脓毒症治疗中CRRT联合抗菌药物使用的相关文献,探讨CRRT对抗菌药物清除的影响,为临床工作提供依据.Sepsis should be defined as life-threatening organ dysfunction caused by a dys-regulated host response to infection. Continuous renal replacement therapy （CRRT） is one of the methods for the clinical treatment of sepsis. For patients undergoing CRRT, rational antimicrobial therapy is very important for the control of patient＇s infection. However, during CRRT, there is no clear guideline for the dose adjustment of antibiotics. In this paper, we analyzed the effect of CRRT combined with antibiotics on sepsis treatment in China and abroad, and discussed its effect on antibiotic clearance, and provided reference for clinical work.

关 键 词：脓毒症 连续性肾脏替代治疗 抗菌药物 清除 

分 类 号：R459.7[医药卫生—急诊医学]