四联疗法联合双歧杆菌四联活菌片根除幽门螺杆菌临床疗效分析  

Clinical efficacy of quadruple therapy combined with bifidobacterium quadruple live-film in the treatment of helicobacter pylori

作　　者：张冰[1] 贾兰芳[1] 张月晓[1] 王艳玲[1] ZHANG Bing JIA Lan-fang ZHANG Yue-xiao WANG Yan-ling(Department of Gastroenterology, Hebei Chengde Medical University Affiliated Hospital, Chengde 067000, Chin)

机构地区：[1]承德医学院附属医院消化内科,河北承德067000

出　　处：《临床军医杂志》2017年第7期712-714,共3页Clinical Journal of Medical Officers

基　　金：承德市科技技术研究与发展计划项目(201606A055)

摘　　要：目的探讨四联疗法联合双歧杆菌四联活菌片治疗幽门螺杆菌相关性胃炎的临床疗效。方法选择2014年8月至2016年6月收治的200例慢性胃炎且幽门螺杆菌(Hp)感染阳性者为研究对象。按照随机数字表法将患者分为A组(四联疗法:枸橼酸铋钾颗粒+埃索美拉唑+呋喃唑酮片+阿莫西林)与B组(于A组治疗基础上采用双歧杆菌四联活菌片),每组各100例,均治疗2周。通过14C尿素呼气试验来评价两组Hp根除情况,分别于治疗前、治疗1周、治疗2周对其临床症状进行评分;观察两组患者不良反应的发生情况。结果 B组Hp根除率93.0%,明显高于A组的75.0%(χ~2=12.05,P<0.05);B组治疗1周、2周临床症状评分分别为(6.68±1.30)分、(3.29±1.32)分,明显低于A组的(7.51±1.26)分、(4.29±1.25)分,组间比较,差异均有统计学意义(P<0.05)。B组不良反应发生率为15.0%,明显低于A组的35.0%(χ~2=10.66,P<0.05)。结论采用四联疗法联合双歧杆菌四联活菌片治疗幽门螺杆菌相关性胃炎,有利于提高幽门螺杆菌根除率,改善其临床症状,且不良反应少,值得推广。Objective To investigate the clinical efficacy of quadruple therapy combined with bifidobacterium quadruple live-film in the treatment of helicobacter pylori-related gastritis. Methods A retrospective study was performed on 200 patients with chronic gastritis combined with helicobacter pylori（ Hp） positive infection who were admitted from August 2014 to June 2016. Patients were randomly divided into Group A（ using quadruple therapy： bismuth potassium citrate particles combined esomeprazole,furazolidone tablets and amoxicillin） and Group B（ on based of the treatment in Group A,using bifidobacterium quadruple live film）,100 cases in each group,and the treatment cycle was 2 weeks. Through14 C urea breath test to evaluate the two groups of Hp eradication,respectively,before treatment,treatment first week,and second week to score their clinical symptoms; two groups of clinical adverse reactions were observed. Results Hp eradication rate in Group B（ 93. 0%） was significantly higher than that in Group A（ 75. 0%）（ χ~2= 12. 05,P 〈0. 05）; the clinical symptom scores in treatment first week and second week was（ 6. 68 ± 1. 30）,（ 3. 29 ± 1. 32）,respectively,which were significantly lower than those in Group A（ 7. 51 ± 1. 26）,（ 4. 29 ± 1. 25）,and the difference had statistical significance（ P 〈0. 05）. The adverse reaction rate in Group B（ 15. 0%） was significantly lower than that in Group A（ 35. 0%）（ χ~2= 10. 66,P 〈0. 05）. Conclusion The treatment of helicobacter pylori-associated gastritis by quadruple therapy combined with bifidobacterium quadruple live-film can improve the eradication rate of helicobacter pylori,improve the clinical symptoms with less adverse reactions,which is worth of popularizing.

关 键 词：幽门螺杆菌相关胃炎 四联疗法 双歧杆菌四联活菌片 

分 类 号：R725.7[医药卫生—儿科]