驱虫药五氯柳胺的合成工艺研究  

STUDY ON THE SYNTHESIS OF OXYCLOZANIDE

作　　者：王学成 苏文杰 朱建民 刘祥宜 Wang Xuecheng Su Wenjie Zhu Jianmin Liu Xiangyi(Changzhou Yabang-QH Pharmachem Co. , Ltd. , Changzhou 213127, Jiangsu, China)

机构地区：[1]常州齐晖药业有限公司,江苏常州213127

出　　处：《精细石油化工》2017年第4期52-55,共4页Speciality Petrochemicals

基　　金："十二五"国家科技支撑计划项目(2015BAD11B01)

摘　　要：以2,4-二氯-6-硝基苯酚为原料,依次通过催化加氢还原,与3,5,6-三氯水杨酸酰氯缩合,并在甲醇/水中加入还原性脱色剂精制得五氯柳胺。总收率由54.8%提高至87.5%,纯度达99.7%,单杂均小于0.2%。产物结构经~1H NMR、元素分析及MS进行了表征。Oxyclozanide was prepared from 2,6-dichloro-4-nitrophenol via Catalytic hydrogenation, condensation with 3,5,6-trichlorosalicylryl chloride, and finally purification by reductive decoloring agent in methanol. The overall yield of oxiconazole nitrate was increased from 54.8% to 87.5%, with a purity of 99.9 % and Individual impurity less than 0.2 %. The structures of the products were characterized by ^1H NMR.MS spectra and organic elemental analysis.

关 键 词：五氯柳胺 催化加氢 2 4-二氯苯酚 3 5 6-三氯水杨酸 驱虫药 

分 类 号：TQ453.21[化学工程—农药化工]