云南含笑果实中倍半萜类化学成分研究  

Sesquiterpenes constituents from fruits of Michelia yunnanensis

作　　者：丁林芬[1] 程彬[1] 晏通 郭亚东[1] 宋流东[1] 王海垠[1] 吴兴德[2] DING Lin-fen CHENG Bin YAN Tong GUO Ya-dong SONG Liu-dong WANG Hai-yin WU Xing-de(School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China State Key Laboratory of Phytochemistry and Plant Resources in Western China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China)

机构地区：[1]昆明医科大学药学院云南省天然药物药理重点实验室,云南昆明650500 [2]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南昆明650201

出　　处：《中草药》2017年第13期2608-2613,共6页Chinese Traditional and Herbal Drugs

基　　金：云南省天然药物药理重点实验室开放研究基金资助项目(2015G004)

摘　　要：目的对云南含笑Michelia yunnanensis果实的化学成分进行研究。方法采用硅胶、Sephadex LH-20等多种色谱技术进行分离纯化,根据波谱数据鉴定化合物的结构。结果从云南含笑果实甲醇提取物中分离得到12个化合物,分别鉴定为13-甲氧基-11β,13-二氢木香烃内酯(1)、毛叶含笑内酯(2)、北美鹅掌楸内酯(3)、鹅掌楸内酯(4)、木香烃内酯(5)、小白菊内酯(6)、11β,13-二氢小白菊内酯(7)、4α,5β-环氧-13-甲氧基-11βH-吉玛烷-1(10)-烯-12,6α-内酯(8)、长莎草醇C(9)、香橙烷-4β,10α-二醇(10)、9-氧代橙花椒醇(11)、11,13-去氢台湾含笑内酯(12)。结论化合物1为新天然产物,并且首次全面报道化合物1和2的1H-NMR、13C-NMR数据。除化合物6,其余化合物均为首次从该植物中分离得到。Objective To study the chemical constituents from fruits of Michelia yunnanensis. Methods The chemical constituents were isolated and purified by column chromatographies on silica gel and Sephadex LH-20. Their structures were elucidated on the basis of spectroscopic data. Results Twelve compounds were isolated from methanol extract of the fruits of M. yunnanensis and the structures were identified as 13-methoxy-11β,13-dihydrocostunolide（1）, lanuginolide（2）, tulipinolide（3）, lipiferolide（4）, costunolide（5）, parthenolide（6）, 11β,13-dihydroparthenolide（7）, 4α,5β-epoxy-13-methoxy-11βH-germacra-1（10）-en-12,6α-olide（8）, cyperusol C（9）, aromadendra-4β,10α-diol（10）, 9-oxonerolidol（11）, and 11,13-dehydrocompressanolide（12）. Conclusion Compound 1 is isolated as a new natural product. ^1H-NMR and ^13C-NMR data of compounds 1 and 2 are reported for the first time. Except compound 6, other compounds are isolated from this plant for the first time.

关 键 词：云南含笑 毛叶含笑内酯 木香烃内酯 小白菊内酯 9-氧代橙花椒醇 11 13-去氢台湾含笑内酯 

分 类 号：R284.1[医药卫生—中药学]