茜草的研究进展  

Research progress on Rubiae Radix et Rhizoma

作　　者：陈毅[1] 王海丽[1] 薛露[1] 单鸣秋[1] 张丽[1] 丁安伟[1] CHEN Yi WANG Hai-li XUE Lu SHAN Ming-qiu ZHANG Li DING An-wei(Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China)

机构地区：[1]南京中医药大学江苏省中药资源产业化过程协同创新中心江苏省方剂高技术研究重点实验室中药资源产业化与方剂创新药物国家地方联合工程研究中心,江苏南京210023

出　　处：《中草药》2017年第13期2771-2779,共9页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81473348);江苏高校优势学科建设工程资助项目(ysxk-2014);江苏高校品牌专业建设工程资助项目(PPZY2015A070)

摘　　要：茜草Rubiae Radix et Rhizoma是我国传统常用中药之一,具有行血、止血、通经活络等功效。茜草的化学成分丰富,以蒽醌类和萘醌类化合物为主,此外还含有环己肽类、萜类、多糖类和微量元素等;其药理活性多样,有止血、抗肿瘤、抗氧化、抗炎、抗菌、升高白细胞及免疫调节等作用;临床应用广泛,对崩漏、子宫异常出血、原发性痛经等妇科疾病和过敏性紫癜、肾性血尿等疾病具有显著的疗效。茜草具有非常重要的研究价值。主要从茜草的化学成分、药理作用、加工炮制和临床应用4方面阐述其近年来的研究进展,以期为茜草相关的研究和应用提供参考。Rubiae Radix et Rhizoma is one of the Chinese materia medica in common use, which has the effect of promoting circulation of blood, hemostasis, activating collaterals, and so on. The chemical constituents of Rubiae Radix et Rhizoma are plentiful which mainly contain anthraquinones and naphthoquinones and cyclic hexapeptides, terpenoids, polysaccharides, and microelement are also included. The pharmacological activities are various which have the effects of hemostasis, antitumor, anti-oxidant, anti-inflammatory, anti-microbial, rising white blood cell and immunoregulation. The clinical applications are also extensive which have the prominent curative effect for gynecological diseases such as metrorrhagia and metrostaxis, abnormal uterine bleeding, primary dysmenorrhea and other diseases such as anaphylactoid purpura, and renal hematuria. Rubiae Radix et Rhizoma has the very important research values. This paper summarized the research progress on Rubiae Radix et Rhizoma in recent years from the aspects of chemical component, pharmacological action, processing and clinical application so as to provide references to further researches and applications of Rubiae Radix et Rhizoma.

关 键 词：茜草 行血 止血 通经活络 蒽醌 萘醌 加工炮制 

分 类 号：R282.71[医药卫生—中药学]