糠酸莫米松鼻喷雾剂联合孟鲁司特钠治疗阻塞性睡眠呼吸暂停低通气综合征疗效及对血浆Orexin-A水平的影响  

Clinical Efficacy of Mometasone Furoate Aqueous Nasal Spray Combined with Montelukast Sodium in Treating OSAHS and Its Effect on Plasma Orexin-A Level

作　　者：滕以书[1] 冼志雄[1] 韩赛红[1] 潘宏光[1] 黎才卫[1] 梁振江[1] Teng Yishu Xian Zhixiong Han Saihong Pan Hongguang Li Caiwei Liang Zhenfiang(Department of Otolaryngology, Shenzhen Children＇s Hospital, Shenzhen, Guangdong, China 518026)

机构地区：[1]广东省深圳市儿童医院耳鼻咽喉科,广东深圳518026

出　　处：《中国药业》2017年第10期41-44,共4页China Pharmaceuticals

基　　金：深圳市科技计划项目[JCYJ20140416141331540]

摘　　要：目的探讨糠酸莫米松鼻喷雾剂联合孟鲁司特钠治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患儿的疗效及对血浆OrexinA水平的影响。方法选择经多导睡眠监测(PSG)确诊为OSAHS的患儿156例,选择45例正常儿童作为对照组。治疗前,测定两组的Orexin-A水平。试验组患儿应用糠酸莫米松鼻喷雾剂联合孟鲁司特钠治疗3个月后,采用放射免疫测定法测定血浆Orexin-A水平;记录PSG检查得到的呼吸暂停低通气指数(AHI)和最低血氧饱和度(LSaO_2)。结果试验组患儿Orexin-A水平治疗前明显高于对照组患儿,治疗后则明显降低(P<0.05);治疗后,试验组患儿LSaO_2水平明显高于治疗前(P<0.05);OSAHS患儿血浆Orexin-A水平与LSaO_2呈负相关,与AHI呈正相关。结论糠酸莫米松鼻喷雾剂联合孟鲁司特钠治疗OSAHS疗效佳,可降低患儿血浆Orexin-A水平,升高LSaO_2水平。患儿Orexin-A水平与LSaO_2呈负相关,与AHI呈正相关,其有望作为评价OSAHS患儿严重程度的指标之一。Objective To investigate the clinical efficacy of Mometasone Furoate Aqueous Nasal Spray combined with Montelukast Sodi- um in treating obstructive sleep apnea hypopnea syndrome（OSAHS） and its effect on plasma Orexin-A level. Methods Totally 156 patients with OSAHS diagnosed by polysomnography（PSG） were selected as the experimental group,45 normal children were selected as the control group. The Orexin-A levels of the two groups were measured before treatment. The experimental group was treated with Mometasone Furoate Aqueous Nasal Spray combined with Montelukast Sodium for 3 months, after treatment, the plasma Orexin- A level was measured by radioimmunoassay,the AHI and minimum LSaO2 were recorded by PSG. Results Before treatment,The Orexin- A lev- els of the experimental group was significantly higher than that of the control group,but it decreased obviously after treatment（P 〈 0. 05）. After treatment,the level of LSaO2 in the experimental group was significantly higher than that before treatment（ P 〈 0.05）. Plasma Orexin-A level was negatively correlated with LSaO2 in children patients with OSAHS, and positively correlated with AHI. Conclusion Mometasone Furoate Aqueous Nasal Spray combined with Montelukast Sodium for treating OSAHS has good effect, it can reduce the plasma Orexin- A level and raise the LSaO2 level in the children patients. The Orexin- A level was negatively correlated with LSaO2 in children patients with OSAHS, and positively correlated with AHI,which could be used as an indicator of the severity of children patients with OSAHS.

关 键 词：糠酸莫米松 孟鲁司特钠 阻塞性睡眠呼吸暂停低通气综合征 OREXIN-A 小儿 

分 类 号：R969.4[医药卫生—药理学] R974[医药卫生—药学]