复方槲皮素乳膏治疗白癜风临床评价  

Clinical Effect of Compound Quercetin Ointment in Treating Leukoderma

作　　者：胡丽敏[1] 孙绍伟[1] 王滨[1] 于鹏飞[1] 魏传梅[1] Hu Limin Sun Shaowei Wang Bin Yu Pengfei Wei Chuanmei(Department of Pharmaceutical, The Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, China 25660)

机构地区：[1]滨州医学院附属医院药学部,山东滨州256603

出　　处：《中国药业》2017年第10期45-47,共3页China Pharmaceuticals

基　　金：山东省滨州市科技发展计划项目[2013ZC1801]

摘　　要：目的观察复方槲皮素乳膏治疗白癜风的临床疗效及安全性。方法将医院皮肤科门诊诊治的76例白癜风患者随机分为3组,治疗组(A组)36例,病变局部外用复方槲皮素乳膏;对照1组(B组)20例,病变局部外用复方甲氧沙林乳膏;对照2组(C组)20例,病变局部外用0.1%他克莫司软膏。结果 3组总有效率分别为72.22%,44.44%和75.00%,A组、C组均明显优于B组(P<0.05);3组不良反应发生率分别为5.56%,60.00%和25.00%,A组、C组明显低于B组(P<0.01),且A组明显低于C组(P<0.05)。结论复方槲皮素乳膏与0.1%他克莫司软膏外涂治疗白癜风疗效相当,较复方甲氧沙林乳膏疗效显著,且不良反应少,值得临床推广。Objective To observe the clinical effect and safety of Compound Quercetin Ointment in treating leukoderma. Methods Totally 76 patients with leukoderma in our hospital were divided into 3 groups,the group A （36 cases） was given Compound Quercetin Oint- ment,the control group l（group B,20 cases） was given Compound Methoxsalen Ointment,and the control group 2（group C,20 cases） was given 0. 1% Compound Tacrolimus Ointment. Results The total effective rates of 3 group were 72.22% ,44.44% ,75.00%, respectively,the group A and group C are obviously better than group B（ P 〈 0. 05）. The incidence rates of adverse reaction in the 3 groups were 5.56% ,60. 00% ,25.00% ,respectively,the group A and group C were obviously lower than group B（P 〈 0. 01）, and the the group A were obviously lower than group C （P 〈 0. 05）. Conclusion Compound Quercetin Ointment and 0.1% Compound Tacrolimus Ointment in treating leukoderma has similar effect,which is more effective than Compound Methoxsalen Ointment,it has less adverse reactions and worthy of clinical promotion.

关 键 词：复方槲皮素乳膏 复方甲氧沙林乳膏 他克莫司软膏 白癜风 临床疗效 安全性 

分 类 号：R969.4[医药卫生—药理学] R986[医药卫生—药学]