消郁安神胶囊对慢性随机温和应激大鼠行为学的影响  

Effect of Xiaoyu Anshen Capsule on Praxiology in Chronic Unpredictable Mild Stress Rats

作　　者：韦丽佳[1,2] 王惠[1] Wei Lijia Wang Hui(Chongqing Medical and Pharmaceutical College, Chongqing, China 400030 Engineering Research Center of Pharmaceutical Sciences, Chongqing, China 400030)

机构地区：[1]重庆医药高等专科学校,重庆400030 [2]重庆市药物制剂工程技术研究中心,重庆400030

出　　处：《中国药业》2017年第13期14-16,共3页China Pharmaceuticals

基　　金：重庆医药高等专科学校校级自然科学一般项目[ygz2013105]

摘　　要：目的观察消郁安神胶囊对慢性随机温和应激(CUMS)大鼠行为学的影响。方法以慢性随机温和应激配合孤养CUMS建立大鼠模型,灌胃给予消郁安神胶囊(3.3 mg/kg,10 mg/kg,30 mg/kg)。通过糖水偏好、高架十字迷宫试验观察大鼠行为学的变化。结果糖水偏好试验结果显示,CUMS大鼠的糖水偏好率明显降低;高架十字迷宫试验中CUMS大鼠进入开臂中的次数和停留时间所占百分比明显比正常组低;给予消郁安神胶囊后能剂量依赖性增加CUMS大鼠的的糖水偏好率,增加CUMS大鼠在开臂中的进入次数和停留时间占比。结论消郁安神胶囊能改善CUMS大鼠的抑郁行为。Objective To investigate the effect of Xiaoyu Anshen Capsule on praxiology in chronic unpredictable mild stress （ CUMS ） rats. Methods CUMS rats models were established by CUMS combined with solitary feeding. The models were given Xiaoyu Anshen Capsule （ 3. 3 mg/kg, 10 mg/kg, 30 mg/kg ） by intragastric administration, and then the praxiology changes in rats were observed through sugar preference and high plus maze experiment. Results The sugar preference experimental results showed that the sucrose preference partial rate of CUMS rats significantly reduced;In high plus maze experiment, the open arms entry times of CUMS rats and the percentage of stay time was significantly reduced than the normal group. Given Xiaoyu Anshen Capsule could dose dependently increase the sucrose preference partial rate of CUMS rats, and also could increase the open arms entry times and residence time ratio. Conclusion Xiaoyu Anshen Capsule can improve the depression praxiology of CUMS rats.

关 键 词：消郁安神胶囊 慢性随机温和应激 糖水偏好率 高架十字迷宫 

分 类 号：R965.2[医药卫生—药理学] R971.3[医药卫生—药学]