复方氟米松软膏联合窄谱中波紫外线治疗玫瑰糠疹40例临床观察  

Clinical Observation of Compound Flumetasone Ointment Combined with Narrow-Band UVB for Treating Pityriasisrosea in 40 Cases

作　　者：王鹏[1] 刘付华[1] 唐岚[1] 江惟苏[1] 陈波[1] Wang Peng Liu Fuhua Tang Lan Jiang Weisu Chen Bo(Qingyuan People＇s Hospital, Qingyuan, Guangdong, China 511518)

机构地区：[1]广东省清远市人民医院,广东清远511518

出　　处：《中国药业》2017年第14期20-22,共3页China Pharmaceuticals

基　　金：广东省清远市社会发展领域自筹经费科技计划项目[2016B037]

摘　　要：目的探讨复方氟米松软膏联合窄谱中波紫外线治疗玫瑰糠疹的疗效及安全性。方法将2016年5月至2017年2月在医院皮肤科就诊的120例玫瑰糠疹患者随机分为3组,各40例。氟米松组患者外涂复方氟米松软膏,早晚各1次;紫外线组患者采用窄谱中波紫外线治疗仪照射治疗,隔日1次;联合组患者采用窄谱中波紫外线照射治疗后外涂复方氟米松软膏。结果治疗1周、2周后,联合组皮损面积和严重程度指数(PASI)评分显著低于氟米松组和紫外线组(P<0.05),但后两组比较,差异无统计学意义(P>0.05)。联合组总有效率为97.50%,显著高于氟米松组的77.50%和紫外线组的75.00%(P<0.05),但后两组比较,差异无统计学意义(P>0.05)。3组不良反应发生率比较,差异无统计学意义(P>0.05)。结论复方氟米松软膏联合窄谱中波紫外线照射治疗玫瑰糠疹效果显著,安全性高,值得临床推广。Objective To investigate the clinical effect of compound flumetasone ointment combined with narrow-band UVB in the treatment of pityriasisrosea. Methods A total of 120 patients with pityriasisrosea treated in the department of dermatology from May 2016 to February 2017 in the hospital were selected and randomly divided into 3 groups,40 cases in each group. The flumetasone group was treated with compound flumetasone ointment,1 day sooner or later. The ultraviolet group was treated with a narrow-band UVB therapeutic apparatus,once every other day. The combined group was treated with compound flumetasone ointment combined with narrow-band UVB. Results 1 and 2 weeks after treatment,the PASI score of the combined group was significantly lower than those of the flumethasone group and the ultraviolet group（ P〈0. 05）. There was no significant difference between the flumethasone group and the ultraviolet group（ P〉0. 05）. The total effective rate in the combined group was 97. 50%,which was significantly higher than 77. 50% in the flumethasone group and 75. 00% in the ultraviolet group（ P〈0. 05）,but there was no significant difference between the flumethasone group and the ultraviolet group（ P〈0. 05）. There were no statistically significant differences in adverse reactions among the 3 groups（ P〉0. 05）. Conclusion Compound flumetasone ointment combined with narrow-band UVB has significant effect and safety on pityriasisrosea,it is worthy of clinical promotion,

关 键 词：复方氟米松软膏 窄谱中波紫外线 玫瑰糠疹 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R986[医药卫生—药学]