超声弹性成像技术在监测肌松药对活体肌肉组织硬度影响中的应用  

Shear wave elastography to monitor the stiffiness of muscle tissue in vivo after injection of muscle relaxant

作　　者：陈菲[1] 张文静[1] 周晓华[1] 邱少东[1] 

机构地区：[1]广州医科大学附属第二医院超声科,510260

出　　处：《国际医药卫生导报》2017年第16期2533-2535,共3页International Medicine and Health Guidance News

基　　金：广州市医药卫生科技项目（20141A010078）

摘　　要：目的应用剪切波弹性成像技术观察不同剂量肌松药对活体兔肌肉组织硬度的影响。方法选取健康新西兰大白兔10只，应用法国Supersonic超声诊断仪测量大腿肌群硬度，单侧大腿肌肉注射肌松药苯磺酸阿曲库铵03,ng／kg体重，5min后重复进行注射，每次注射后测量肌群硬度。分析肌松药对肌肉组织硬度的影响。结果注射肌松药前大腿肌群硬度Emean值为（13．20±1．50）kPa，Esd值为（0．16±0．02）kPa；第一次注射肌松药后大腿肌群硬度Emean值为（10．00±3．20）kPa，Esd值为（1．15±0．27）kPa；第二次注射肌松药后实验兔死亡，大腿肌群硬度Emean值为（21．30±2．80）kPa，Esd值为（1．20±0．34）kPa；注射前后大腿肌群硬度比较差异均有统计学意义（均P〈0．05）。结论剪切波弹性成像技术可用于反应不同剂量肌松药及肌松药过量致死对活体兔肌肉组织硬度的影响，可为超声弹性成像技术检测肌肉组织硬度提供分子学基础，同时，可为临床定量麻醉时定量肌松提供影像学指标。Objective To use shear wave elastography to monitor the effect of different doses of muscle relaxant on the stiffiness of muscle tissue in vivo. Methods 10 healthy New Zealand white rabbits were selected, the stiffiness of muscles of thigh was measured by France Supersonic diasonograph. Unilateral thigh muscles were given injection of 0.3 mg/kg muscle relaxant atracurium besylate, repeated injection five minutes later. The stiffiness of muscles of thigh was measured after each injection. The effect of muscle relaxant on the stiffiness of muscle tissue was analyzed. Results Before injection, E value of muscles was （13.2±1.5）kPa, the Esd value was （0.16±0.02）kPa; those after the first injection were （10.0±3.2）kPa and （1.15±0.27）kPa; the rabbits died after the second injection, those were （21.3~2.8）kPa and （1.20±0.34）kPa; there were statistically significant differences in the stiffiness of muscles of thigh before and after injection （P〈0.05）. Conclusions Shear wave elastography can reflect the effect of different doses of muscle relaxant and death caused by drug overdose on the stiffiness of muscle tissue in vivo, which may provide a molecular basis for the detection of,muscle tissue stiffness by elastography, and may provide imaging parameters for quantitative muscle relaxation in clinical quantitative anesthesia.

关 键 词：剪切波 超声弹性成像 肌肉 定量肌松 

分 类 号：R445.1[医药卫生—影像医学与核医学] R969[医药卫生—诊断学]