复方米非司酮和米非司酮终止早期妊娠的临床效果比较  

Comparison of the clinical effect between compound mifepristone and mifepristone on the termination of early pregnancy

作　　者：朱燕莉[1] 

机构地区：[1]河池市人民医院妇产科,广西547000

出　　处：《中国临床新医学》2017年第7期665-668,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的比较复方米非司酮和米非司酮终止早期妊娠的效果。方法将2013-01~2013-12到该院自愿要求终止妊娠的停经≤49 d的早期妊娠妇女120例,根据接诊的先后顺序分为两组。观察组60例,服复方米非司酮1片(每片含米非司酮30 mg,双炔失碳酯5 mg),连服2 d,第3天口服米索前列醇0.6 mg。对照组60例,服米非司酮25 mg,早晚各1次,第3天服米非司酮50 mg后,口服米索前列醇0.6 mg。观察两组引产结果。结果观察组完全流产56例,不全流产3例,失败1例。对照组完全流产48例,不全流产8例,失败4例。观察组引产效果优于对照组(P<0.05),观察组孕囊排出时间、流产后阴道出血时间较对照组短,差异均具有统计学意义(P<0.01)。结论复方米非酮司联合米索前列醇引产效果优于米非司酮联合米索前列醇。Objective To compare the clinical effects between compound mifepristone and mifepristone on termination of early pregnancy. Methods According to the orders of visting the doctors,120 women with early pregnancy less than 49 day＇s gestation were divided into two groups. Each patient in the observation group（ n = 60） took one tablet of compound mifepristone（ each tablet contains mifepristone 30 mg and anordrin 5 mg） every day for two days and misoprostol 0. 6 mg on the third day. Each patient in the control group（ n = 60） took mifepristone 25 mg in the morning and in the evening respectively for two days and mifepristone 50 mg followed by misoprostol 0. 6 mg on the third day. The efficacy of the termination of early pregnancy was compared between the two groups. Results In the observation group,56 cases had complete abortion,3 cases had incomplete abortion and 1 case failed to terminate early pregnancy. In the control group,48 cases had complete abortion,8 cases had incomplete abortion and 4 cases failed to terminate early pregnancy. The observation group had a better effect on inducing abortion than the control group（ P〈0. 05）. The observation group had shorter discharging time of pregnancy sac and less bleeding time than the control group（ P〈0. 01）. Conclusion Compound mifepristone combined with misoprostol is more effective than mifepristone in combination with misoprostol in the termination of early pregnancy.

关 键 词：复方米非司酮 米非司酮 药物流产 米索前列醇 双炔失碳酯 

分 类 号：R719.31[医药卫生—妇产科学]