慢性乙型肝炎患者血清IL-2、IL-4、IL-10及IFN-γ水平与肝组织病理的相关性  

Relationship between serum levels of IL-2,IL-4,IL-10 and IFN-γ and hepatic tissue pathology in patients with chronic hepatitis B

作　　者：张佳光[1] 王永华[1] 黄利青[1] 石次国[1] 

机构地区：[1]三峡大学第三临床医学院葛洲坝集团中心医院感染性疾病科,湖北宜昌443002

出　　处：《中国肝脏病杂志（电子版）》2017年第2期67-69,共3页Chinese Journal of Liver Diseases：Electronic Version

基　　金：葛洲坝集团项目(2008KJ-21)

摘　　要：目的探究慢性乙型肝炎患者血清IL-2、IL-4、IL-10、IFN-γ活性与肝组织病理的相关性。方法选取2010年1月至2015年12月于葛洲坝中心医院住院的90例慢性乙型肝炎(CHB)患者为研究对象,测定所有患者血清IL-2、IL-4、IL-10和IFN-γ水平并同步进行肝组织活检,分析上述各指标与肝组织病理的相关性。结果 90例CHB患者中,肝组织炎症活动度G1~G4期分别有24例、23例、21例、23例,不同肝组织炎症活动度患者血清IL-2、IL-4、IL-10及IFN-γ水平的差异有统计学意义(F值分别为42.6、58.2、52.3、36.2,P值分别为0.006、0.005、0.007、0.008),与肝组织炎症活动度呈负相关(r值分别为-0.596、-0.609、-0.632、-0.621,P值分别为0.007、0.006、0.005、0.006)。90例CHB患者中肝纤维化分期S_1~S_4分别有25例、25例、20例、20例,不同肝纤维化分期患者血清IL-2、IL-4、IL-10和IFN-γ水平的差异有统计学意义(F值分别为53.2、58.7、56.2、35.5,P值分别为0.006、0.005、0.007、0.008),与肝纤维化程度均呈负相关(r值分别为-0.625、-0.608、-0.643、-0.632,P值分别为0.007、0.006、0.008、0.007)。结论 CHB患者血清IL-2、IL-4、IL-10及IFN-γ水平与肝组织炎症活动度和肝纤维化程度均呈负相关。Objective To investigate the relationship between serum levels of IL-2,IL-4,IL-10 and IFN-y and hepatic tissue pathology in patients with chronic hepatitis B.Methods Total of 90 cases with chronic hepatitis B（CHB） in Gezhouba Central Hospital from January 2010 to December 2015 were selected.All patients were underwent liver biopsy and the serum levels of IL-2,IL-4,IL-10 and IFN-y were detected.The relationship between the above indexes and hepatic tissue pathology were analyzed.Results The number of patients with CHB in G1~G4 stage were 24,23,21 and 23,respectively.The serum levels of IL-2,IL-4,IL-10 and EFN-y in patients with different hepatic inflammatory activity were statistically different（F = 42.6,58.2,52.3,36.2;P = 0.006,0.005,0.007,0.008）,and were negatively related with hepatic inflammatory activity（r =-0.596,-0.609,-0.632,-0.621;P = 0.007,0.006,0.005,0.006）.The number of patients with CHB in S1~S4 stage were 25 cases,25 cases,20 cases and 20 cases,respectively.The serum levels of IL-2,IL-4,IL-10 and IFN-y in patients with different liver fibrosis stage were statistically different（F = 53.2,58.7,56.2,35.5;P = 0.006,0.005,0.007,0.008）,and were negatively related with liver fibrosis stage（r =-0.625,-0.608,-0.643,-0.632;P = 0.007,0.006,0.008,0.007）.Conclusion The serum levels of IL-2,IL-4,IL-10 and TFN-γ in patients with CHB were negatively related with hepatic inflammatory activity and liver fibrosis stage.

关 键 词：肝炎 乙型 慢性 细胞因子 肝脏活组织检查 

分 类 号：R512.62[医药卫生—内科学]