早期微量喂养可提高新生儿耐受并降低胆汁淤积  

Early Micro Feeding could Improve Neonatal Tolerance and Reduce Cholestasis of the Newborn

作　　者：苏维[1] 宋新志[1] 邝爱玲[2] 贺春华[2] 

机构地区：[1]湘南学院,郴州423000 [2]湘南学院附属医院,郴州423000

出　　处：《基因组学与应用生物学》2017年第7期2717-2721,共5页Genomics and Applied Biology

基　　金：郴州湘南学院资助

摘　　要：为了探讨早期微量喂养提高新生儿耐受和降低胆汁淤积的效果研究,选取2012年2月至2014年2月来我院进行抢救的出现急性呼吸衰竭患儿120例,按照随机数字表法将其分为A组和B组。给予A组患儿全静脉营养,给予B组患儿早期微量喂养,对比治疗期间两组患儿耐受情况和出现不良反应情况;记录两组患儿体重恢复所需时间、进行机械通气的总时间、患儿达到全量胃肠营养的总时间和住院时长;比较两组患儿出现胆汁淤积例数;对比干预前后患儿血清总胆红素、血清总胆汁酸和结合胆红素水平。研究显示,B组患儿耐受人数显著高于A组患儿(p<0.05);B组患儿胃肠功能紊乱与坏死性小肠结肠炎数量明显低于A组患儿(p<0.05);B组患儿达全量胃肠营养总时长和住院时长都明显短于A组患儿(p<0.05)。B组患儿出现胆汁淤积例数显著少于A组患儿(p<0.05)。治疗后B组患儿TBIL、DBIL、TBA水平均显著低于A组患儿(p<0.05)。因此,对进行机械通气的新生儿采用早期微量喂养,有利于提高患儿治疗耐受性,减少并发症的发生,缩短患儿住院时长,值得临床推广。In order to explore the effect of early micro feeding on improving neonatal tolerance and reducing cholestasis, 120 cases of acute respiratory failure children in our hospital from February, 2012 to February, 2014 were selected and divided into group A and group B according to the random number table method. Children in the group A were given total intravenous nutrition, while those in the group B were given early micro feeding. We compared the tolerance and adverse reactions between the two groups during the treatment period and recorded the time of recovery of body mass, the time of mechanical ventilation, the duration of reaching the total amount of gastrointestinal nutrition and the time of stay in hospital. The numbers of cases of cholestasis in two groups of patients were compared. The total bilirubin of serum, total bile acid of serum and conjugated bilirubin were compared before and after the intervention. The results showed that the number of tolerance patients in the group B was significantly higher than that in the group A （p〈0.05）. Patients with gastrointestinal dysfunction and enteroeolitis in the group 13 were significantly fewer than those in the group A （p〈0.05）. The time of reaching total amount of gastrointestinal nutrition and the time of stay in hospital of group B were significantly shorter than those in the group A （/9〈0.05）. The number of patients with cholestasis in group B was significantly smaller than that in group A （p 〈0.05）. After treatment, the levels of TBA, DBIL and TBIL in B group were significantly lower than those in group A （p〈0.05）. Therefore, the application of early micro feeding for mechanical ventilation in the newborn waseffective to improve the treatment tolerance, reduce the incidence of complications and shorten the length of hospital stay. It was worthy of clinical promotion.

关 键 词：机械通气 新生儿 早期微量喂养 全静脉营养 

分 类 号：R722.1[医药卫生—儿科]