磷酸化蛋白质组学在哺乳动物精子研究中的应用  

The Application of Phosphoproteomics in Mammalian Sperm Research

作　　者：张鹏飞[1] 濮黎萍 王焕景[1] 赵秀玲[1] 陈富美[1] 陆阳清[1] 张明[1] 

机构地区：[1]广西大学动物繁殖研究所亚热带农业生物资源保护与利用国家重点实验室,南宁530004

出　　处：《基因组学与应用生物学》2017年第7期2862-2866,共5页Genomics and Applied Biology

基　　金：国家自然科学基金(31160421);广西高等学校高水平创新团队及卓越学者计划项目(201338)共同资助

摘　　要：蛋白质磷酸化是蛋白质翻译后最普遍、最重要的修饰之一,是生物体内一种普通的调节方式,参与调控细胞增殖、信号转导、新陈代谢、肿瘤发生等分子机能,并在精子信号转导和酶合成表达的过程中起重要作用。对精子磷酸化蛋白的研究有助于深入了解精子发生、运输、获能,以及精卵识别的调控机理。因此,在磷酸化蛋白组学的层面上研究精子的各项机能可以为雄性不育更深层的研究提供一条新的道路。Phosphorylation is one of the most common and important post-translational modifications of proteins, which is an ordinary way of organism regulation and participates in controlling molecular mechanism such as cell proliferation, signal transduction, metabolism, and tumor/genesis. Furthermore, it plays an important role in the process of sperm signal transduction and the expression of enzymatic synthesis. Researches about phosphorylated proteins of sperm contribute to the further understanding of the molecular mechanism of spermatogenesis, transportation, capacitation, and sperm-egg recognition. Therefore, the study of the functions of sperm on phosphoproteomics level could provide a new way for further research on male sterility.

关 键 词：哺乳动物 精子 磷酸化蛋白质组学 

分 类 号：S814.1[农业科学—畜牧学]