磷酸肌酸钠对急性胎儿窘迫的临床疗效及安全性评价  

Clinical Effect and Safety of Creatine Phosphate Sodium for Treating Acute Fetal Distress

作　　者：赖永娥 陈小强 杨成刚 欧有权 张朝阳 Lai Yonge Chen Xiaoqiang Yang Chenggang Ou Youquan Zhang Zhaoyang(Foshan Chancheng Central Hospital, Foshan, Guangdong, China 52800)

机构地区：[1]广东省佛山市禅城区中心医院,广东佛山528000

出　　处：《中国药业》2017年第12期80-82,共3页China Pharmaceuticals

摘　　要：目的探讨磷酸肌酸钠静脉注射对因急性胎儿窘迫行剖宫产产妇的临床疗效及安全性。方法选择医院2013年6月至2014年12月诊断为急性胎儿窘迫需行剖宫产产妇120例,随机分为观察组和对照组,各60例。两组均给予剖宫产手术常规处理,对照组于麻醉前10 min给予0.9%氯化钠注射液20 m L静脉注射,观察组于麻醉前10 min给予注射用磷酸肌酸钠1.0 g加20 m L 0.9%氯化钠注射液静脉注射。结果观察组出生后1 min新生儿Apgar评分明显高于对照组(P<0.05),出生后5 min和10 min Apgar评分两组间无显著差异(P>0.05)。观察组新生儿脐静脉血二氧化碳分压(PCO_2)及p H水平明显高于对照组(P<0.05),氧分压(PO_2)及剩余碱(BE)水平明显低于对照组(P<0.05),两组间碳酸氢根离子(HCO_3^-)无显著差异(P>0.05)。观察组新生儿脐静脉血肌钙蛋白I(cTnI)水平为(0.08±0.02)μg/L,明显低于对照组的(2.03±0.88)μg/L(P<0.05)。治疗过程中,两组产妇及新生儿均未出现明显不良反应。结论因急性胎儿窘迫行剖宫产术前静脉注射磷酸肌酸钠,可提高新生儿Apgar评分,改善胎儿缺血、缺氧及酸中毒状况,有利于新生儿维持内环境的稳定,同时有利于预防新生儿心肌损伤,具有较高的临床应用价值。Objective To investigate the clinical efficacy and safety of Creatine Phosphate Sodium for treating parturient women accepted cesarean section because of children with acute fetal distress. Methods Totally 120 parturient women needed to accept cesarean section because of children with acute fetal distress in our hospital from June 2013 to December 2014 were randomly divided into the observa-tion group and the control group,60 cases in each group. The control group was treated with intravenous injection of 20 mL 0. 9%Sodium Chloride Injection at 10 min before anesthesia,the observation group was given intravenous injection of 1. 0 g Creatine Phos-phate Sodium for Injection and 20 mL 0. 9% Sodium Chloride Injection at 10 min before anesthesia. Results The 1 min Apgar score of the observation group was significantly higher than that in the control group（P 〈 0. 05）,the Apgar scores of 5,10 min after birth in the two groups were no significantly different（P 〉 0. 05）. The levels of pH and PCO2 in the observation group were significantly higher than those in the control group,but the levels of PO2 and BE were significantly lower than those in the control group（P 〈 0. 05）,and the levels of HCO3- between the two groups were no significant difference（P 〉 0. 05）. The level of neonatal umbilical vein cTnI in the observation group was （0. 08 ± 0. 02）μg/L,which was significantly lower than （2. 03 ± 0. 88）μg/L in the control group（P 〈 0. 05）. No obvious adverse reactions occurred in the two groups. Conclusion Intravenous injection of Creatine Phosphate Sodium before cesare-an section for acute fetal distress can improve the neonatal Apgar score and the status of fetal ischemia,hypoxia and acidosis,it is ben-eficial to maintain the stability of the internal environment of newborns,and is also beneficial to prevent myocardial damage in new-borns,which has high clinical application value.

关 键 词：急性胎儿窘迫 新生儿 磷酸肌酸钠 临床疗效 安全性 

分 类 号：R969.4[医药卫生—药理学] R977[医药卫生—药学]