原发性高血压不同危险分层患者RDW-CV、MMP-2、MMP-9、TIMP-1的观察研究  

Observational study of RDW-CV,MMP-2,MMP-9 and TIMP-1 in patients with essential hypertension of different risk stratification

作　　者：江琼[1] 庄和[2] 郑行春[1] JIANG Qiong ZHUANG He ZHENG Xing-chun(Department of Cardiology, Affiliated Union Hospital of Fujian Medical University, Fujian Institute of Coronary Heart Disease, Fuzhou, Fujian, 350001, China)

机构地区：[1]福建医科大学附属协和医院心血管内科,福建省冠心病研究所,福建福州350001 [2]福建医科大学附属协和医院检验科,福建省冠心病研究所,福建福州350001

出　　处：《心血管康复医学杂志》2017年第3期250-254,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:观察原发性高血压(EH)不同危险分层患者红细胞分布宽度变异系数(RDW-CV)、基质金属蛋白酶(MMP)-2、MMP-9、基质金属蛋白酶组织抑制剂(TIMP)-1水平变化情况。方法:选择2015年10月~2016年9月期间我科收治的105例EH患者为观察对象(高血压组),根据高血压危险分层分为低危组(34例)、中危组(38例)和高危及极高危组(33例)。选择同期年龄、性别匹配的105例体检者为健康对照组。测定比较各组RDW-CV、血清MMP-2、MMP-9和TIMP-1水平,多元Logistic回归分析上述指标与高血压的关系。结果:与健康对照组比较,高血压组RDW-CV[(12.57±1.46)比(14.54±1.82)]、血清MMP-2[(121.71±18.86)ng/ml比(155.43±40.81)ng/ml]、MMP-9[(109.72±21.80)ng/ml比(191.23±53.05)ng/ml]和TIMP-1水平[(59.42±9.41)ng/ml比(83.64±15.82)ng/ml]均显著升高,P<0.05或<0.01。与低危组比较,中危组、高危及极高危组的RDW-CV[(13.35±1.54)比(14.43±1.17)比(15.90±1.81)]、血清MMP-2[(131.21±35.24)ng/ml比(152.16±33.15)ng/ml比(184.16±37.14)ng/ml]、MMP-9[(163.95±38.61)ng/ml比(198.70±43.52)ng/ml比(232.83±54.12)ng/ml]和TIMP-1水平[(73.15±13.12)ng/ml比(83.78±10.22)ng/ml比(94.27±16.77)ng/ml]均显著升高,且高危及极高危组的显著高于中危组,P<0.05或<0.01。多元Logistic回归分析显示RDW-CV、MMP-2、MMP-9和TIMP-1是高血压的独立危险因素(OR=2.248~2.725,P<0.05或<0.01)。结论:红细胞宽度变异系数及细胞外基质金属蛋白酶MMP-2、MMP-9、基质金属蛋白酶组织抑制剂(TIMP)-1是高血压的独立危险因素,应给予积极的监测与干预。Objective： To observe changes of variation of red blood cell distribution width-coefficient （RDW-CV）, levels of matrix metalloproteinase （MMP） -2, MMP-9 and tissue inhibitor of metalloproteinases （TIMP） -1 in patients with essential hypertension （EH） of different risk stratification. Methods： A total of 105 EH patients treated in our department from Oct 2015 to Sep 2016 were regarded as EH group. According to hypertension risk stratifica- tion, they were divided into low risk group （n = 34）, medium risk group （n = 38） and high- and extremely high risk group （n = 33）. Another 105 subjects with corresponding age and gender were selected as healthy control group during the same period. RDW-CV, serum levels of MMP-2, MMP-9 and TIMP-1 were measured and compared among all groups. Multivariate Logistic regression analysis was used to analyze relationship among above indexes and hyper- tension. Results： Compared with healthy control group, there were significant rise in RDW-CV [ （12.57 ± 1.46） vs. （14.54 ± 1.82）], serum levels of MMP-2 [（121.71 ± 18. 86） ng/ml vs. （155.43 ± 40.81） ng/ml], MMP-9 [-（109.72 ± 21.80） ng/ml vs. （191.23 ± 53.05） ng/ml] and TIMP-1 [- （59.42 - 9.41） ng/ml vs. （83.64 ± 15.82） ng/ml] in EH group, P〈0. 05 or 〈0.01. Compared with low risk group, there were significant rise in RDW-CV [ （13.35 ± 1.54） vs. （14. 43 ± 1.17） vs. （15.90 ± 1.81）], serum levels of MMP-2 E （131.21 ± 35. 24） ng/ml vs. （152.16 ± 33.15） ng/ml vs. （184.16±37.14） ng/ml], MMP-9 [ （163.95 ± 38. 61） ng/ml vs. （198.70 ± 43.52） ng/ml vs. （232.83 ± 54. 12） ng/ml] and TIMP-1 [ （73.15 ± 13.12） ng/ml vs. （83.78 ± 10.22） ng/ml vs. （94. 27 ± 16.77） rig/ ml] in medium risk group, high- and extremely high risk group, and those of highand extremely high risk group were significantly higher than those of medium risk group, P〈0.05 or 〈0.01. Multivariate Logistic regression a- nalysis indicated that RDW-CV, M

关 键 词：高血压 基质金属蛋白酶类 心室重构 

分 类 号：R544.109[医药卫生—心血管疾病]