狗舌草的化学成分研究  

Study on Chemical Constituents of Tephroseris Kirilowii

作　　者：唐雨[1] 刘艳霞[1] 张宏伟[1] Tang Yu Liu Yanxia Zhang Hongwei(Teaching and Research Section of Pharmacognosy and Natural Pharmaceutical Chemistry in College of Pharmacy, 3rd Military Medical University, Chongqing, China 40003)

机构地区：[1]中国人民解放军第三军医大学药学院生药学与天然药物化学教研室,重庆400038

出　　处：《中国药业》2017年第11期16-18,共3页China Pharmaceuticals

基　　金：国家青年自然科学基金项目[81202869]

摘　　要：目的探讨狗舌草的化学成分。方法采用硅胶,RP-C_(18),Sephadex LH-20和高效液相色谱法等色谱方法对狗舌草进行分离、纯化,根据化合物的理化性质和波谱学方法对狗舌草化学成分进行结构鉴定。结果从狗舌草中分离得到6个化合物,分别鉴定为白杨素(chrysin,1),芹菜素(apigenin,2),山柰酚(kaempferol,3),金合欢素(acacetin,4),异鼠李素-3-O-β-D-吡喃葡萄糖苷(isorhamnetin-3-O-β-D-glucopyranoside,5),咖啡酸乙酯(caffeic acid ethyl ester,6)。结论 6个化合物均为首次从狗舌草属中分离得到。Objective To study the chemical constituents of Tephroseris Kirilowii. Methods The silica gel,RP-C18,Sephadex LH-20 and HPLC methods were adopted to isolate and purify the Tephroseris Kirilowii,and thechemical constituents were elucidated by the physicochemical properties and spectral analysis. Results 6 kinds of compounds were obtained and identified aschrysin（1）, apigenin（2）,kaempferol（3）, acacetin（4）, isorhamnetin-3-O-β-D-glucopyranoside（ 5）, caffeic acid ethyl ester（6）. Conclusion The 6 kinds of compounds are isolated from Tephroseris Kirilowii for the first time.

关 键 词：狗舌草 化学成分 成分分离 结构鉴定 

分 类 号：R284.2[医药卫生—中药学] R282.6[医药卫生—中医学]