地屈孕酮片联合中药人工周期治疗子宫内膜异位症致不孕疗效观察  

Efficacy of Dydrogesterone Tablets Combined with Artificial Menstrual Cycle Induction by Traditional Chinese Medicine in Treating Infertility Caused by Endometriosis

作　　者：付蒙[1] 吕晓杰[1] Fu Meng Lü Xiaojie(Department of Obstetrics and Gynecology, Haidian Maternal and Children Health Hospital, Beijing, China 100080)

机构地区：[1]北京市海淀区妇幼保健院妇产科,北京100080

出　　处：《中国药业》2017年第11期44-47,共4页China Pharmaceuticals

摘　　要：目的探讨地屈孕酮片联合中药人工周期治疗CA_(125)阳性子宫内膜异位症(EMT)致不孕患者的临床疗效。方法将2013年1月至2015年6月收治的CA_(125)阳性EMT不孕患者136例,随机分为观察组和对照组,各68例,观察组给予地屈孕酮片联合中药人工周期治疗,对照组患者仅给予地屈孕酮片治疗,3个月经周期为1个疗程,连续治疗2个疗程,随访1年,比较两组患者妊娠率及未妊娠患者血清激素水平、痛经发生率、合并子宫内膜息肉(EP)比例、合并未破裂卵泡黄素化综合征(LUFS)比例。结果随访中,观察组成功妊娠率为48.51%,显著高于对照组的25.00%(P<0.05);观察组治疗后未孕者痛经比例为13.33%,CA_(125)为(20.6±4.7)U/mL,FSH/LH>2者为13.33%,PRL>25 ng/mL者为10.00%,显著低于对照组的34.88%,(36.8±6.5)U/mL,34.99%,32.56%(P<0.05);观察组治疗后未孕者合并EP(10.00%)、合并LUFS比例(26.67%)均低于对照组的13.95%和41.86%,但差异无统计学意义(P>0.05);两组均未出现严重不良反应。结论地屈孕酮片联合中药人工周期治疗方案可缓解痛经,显著改善EMT致不孕患者卵巢功能,有助于提高临床妊娠率。Objective To observe the clinical efficacy of Dydrogesterone Tablets combined with artificial menstrual cycle induction by traditional Chinese medicine（ TCM） in treating CA125 positive infertility caused byendometriosis（ EMT）. Methods Totally 136 patients with CA125 positive infertility caused by EMT from January 2013 to June 2015 were selected and randomly divided into the observation group and the control group, 68 cases in each group. The observation group was given Dydrogesterone Tablets combined with artificial menstrual cycle induction by TCM,the control group was given Dydrogesterone Tablets. Three menstrual cycles for a course,continuously for 2 courses,all patients were followed up for 1 year. The pregnancy rate in the two groups were compared,besides,the serum hormone level, incidence of dysmenorrhea, proportion of endometrial polyps（ EP）, proportion of luteinized unruptured follicles syndrome（ LUFS） in non-pregnant women in the two groups were also compared. Results During follow-up, the successful pregnancy rate of the observation group was 48. 51%,which was significantly higher than 25. 00% of the control group（ P〈0. 05）. After treatment,the incidence rate of dysmenorrhea in the observation group was 13. 33%,CA125 was（ 20. 6 ± 4. 7） U/mL,proportion of FSH/LH〉 2 was 13. 33%,proportion of PRL 〉25 ng/mL was 10. 00%,which were significantly lower than 34. 88%,（ 36. 8 ± 6. 5） U/mL,34. 99%,32. 56% in the control group（ P〈0. 05）. After treatment,the proportions of non-pregnant women associated with EP（ 10. 00%）,LUFS（ 26. 67%）in the observation group were lower than 13. 95% and 41. 86% in the control group, but the differences without statistically significance（ P〉0. 05）. There were no serious adverse reactions in the two groups. Conclusion Dydrogesterone Tablets combined with artificial menstrual cycle induction by TCM can significantly alleviate dysmenorrhea,significantly improve the ovarian function of EMT infertility patients,and help to improve the

关 键 词：子宫内膜异位症 不孕 地屈孕酮片 中药人工周期 

分 类 号：R969.4[医药卫生—药理学] R984[医药卫生—药学]