微剂量肝素联合冷沉淀治疗新生儿弥散性血管内凝血的临床效果分析  

Clinical efficacy analysis of microdose of heparin combined with cold precipitation in the treatment of neonatal diffuse intravascular coagulation

作　　者：赵锦英 蒋晓梅 蒙淑芳 ZHAO Jin-Ying JIANG Xiao-Mei MENG Shu-Fang(People＇s Hospital of Laibin, Guangxi Zhuang Autonomous Region, Laibin 546100, China)

机构地区：[1]广西壮族自治区来宾市人民医院,广西来宾546100

出　　处：《转化医学电子杂志》2017年第6期43-45,48,共4页E-Journal of Translational Medicine

基　　金：来宾市科学研究与技术开发计划项目(来科转163014)

摘　　要：目的:探讨微剂量肝素联合冷沉淀治疗新生儿弥散性血管内凝血(DIC)的临床效果及安全性.方法:选取广西壮族自治区来宾市人民医院收治的患有弥散性血管内凝血疾病的新生儿40例,随机分为对照组(n=20)和治疗组(n=20).对照组患儿接受原发病治疗;治疗组患儿在积极治疗原发病的基础上给予皮下注射微剂量肝素(24 U/kg·d)联合冷沉淀进行治疗.比较两组的临床治疗效果、机体凝血功能恢复正常时间和凝血功能障碍疾病临床治疗总时间、治疗前后凝血功能相关指标的改善幅度、住院治疗期间出现的不良反应情况.结果:治疗组的有效率明显优于对照组,差异具有统计学意义(P<0.05);治疗组的机体凝血功能恢复正常时间(5.11±0.86d)和凝血功能障碍疾病临床治疗总时间(7.68±2.05 d)明显短于对照组(9.43±1.58 d,13.75±2.64 d),差异具有统计学意义(P<0.05);治疗组治疗后凝血功能相关指标的改善幅度明显大于对照组,差异具有统计学意义(P<0.05);住院治疗期间两组出现的不良反应情况比较,差异无统计学意义(P>0.05).结论:微剂量肝素联合冷沉淀治疗新生儿弥散性血管内凝血临床效果显著,未见明显不良反应,具有较高的安全性.AIM： To study the clinical efficacy and safety of micredose of heparin combined with cold precipitation in the treat- ment of neonatal diffuse intravascular coagulation （DIC）. METHODS： A total of 40 newborns with diffuse intravascular coagulation admitted into People＇s Hospital of Laibing, Guangxi Zhuang Autonomous Region were randomly divided into control group and treatment group, with 20 cases in each group. The con- trol group was given active treatment merely, while the treatment group was given active treatment combined with subcutaneously microdose of heparin （24 U/kg ± d） and cold precipitation treat- ment. The clinical curative effect, the time of blood coagulation returning to normal, the total clinical treatment time of blood coagulation dysfunction disease, the magnitnte of improvement of related indicators of blood coagulation function and the adverse reactions during hospitalization were compared. RESULTS： The efficiency of treatment group was obviously superior to the control group, ＂with ststistically significant difference （P〈0.05）. The time of blood coagulation function returning to normal （ 5.11 ± 0.86 d） and the total clinical treatment time of blood coagulation dysfunc- tion disease （7.68±2.05 d） in treatment group were significantly shorter than those of the control group（9.43±1.58 d, 13.75±2.64 d）, with ststistically significant differences （P 〈 0. 05 ）; The improvement of blood coagulation function related indexes after treatment in treatment group was significantly greater than that of the control group, with a ststistically significant difference （P〈0.05）. The differnce in adverse reactions during hospitaliza- tion was not significant. CONCLUSION： Micro-dose of heparin combined with cold precipitation has a significant effect in the treatment of neonatal diffuse intravascular coagulation, with high security and no obvious adverse reaction.

关 键 词：微剂量肝素 冷沉淀 弥散性血管内凝血 新生儿 

分 类 号：R722.1[医药卫生—儿科]