头发中氯硝西泮的分段分析在药物辅助犯罪案件中的作用  

The Role of Segmental Analysis of Clonazepam in Hair in Drug Facilitated Cases

作　　者：陈航[1] 向平[1] 沈敏[1] 

机构地区：[1]司法部司法鉴定科学技术研究所上海市法医学重点实验室上海市司法鉴定专业技术服务平台,上海200063

出　　处：《法医学杂志》2017年第3期252-257,共6页Journal of Forensic Medicine

基　　金："十三五"国家重点研发计划资助项目(2016YFC0800704);上海市科委资助项目(15DZ1207500);中央级科研院所基本科研业务资助项目(GY2017G-8);上海市法医学重点实验室资助项目(17DZ2273200);上海市司法鉴定专业技术服务平台资助项目(16DZ2290900)

摘　　要：目的通过分段分析头发中的氯硝西泮,对药物辅助犯罪案件中受害人的摄药频度及摄药史进行推断。方法采用液氮冷冻研磨技术联合超声浴技术,以液相色谱-串联质谱法,对6名不同案件中受害人的头发分段分析,并测定各头发段中的氯硝西泮及7-氨基氯硝西泮的含量。结果 6名受害人的部分头发段中均检出氯硝西泮及其代谢物7-氨基氯硝西泮,且头发中药物峰值浓度的出现时间与受害人自述摄药时间相一致。结论头发分段分析可提供摄药频度与摄药时间信息,在药物辅助犯罪案件中具有独特的证据价值。Objective To infer the frequency of dosage and medication history investigate of the victims in drug facilitated cases by the segmental analysis of clonazepam in hair. Methods Freezing milling under liquid nitrogen environment combined with ultrasonic bath was used as sample pretreatment in this study, and liquid chromatography-tandem mass spectrometry was used for the segmental analysis of the hair samples collected from 6 victims in different cases. The concentrations of clonazepam and 7-aminoclonazepam were detected in each hair section. Results Clonazepam and its metabolite 7-aminoclonazepam were detected in parts of hair sections from the 6 victims. The occurrence time of drug peak concentration was consistent with the intake timing provided by victims. Conclusion Segmental analysis of hair can provide the information of frequency of dosage and intake timing, which shows an unique evidential value in drug facilitated crimes.

关 键 词：法医毒理学 氯硝西泮 头发 化学 分析 药物辅助犯罪 

分 类 号：DF795.1[医药卫生—法医学]