Dermoscopic Features and Gene Mutation in the Mevalonate Pathway of Five Sporadic Patients with Porokeratosis  

作　　者：Rui-Feng Sun Hui Chen Wei Zhu Shi Lian 

机构地区：[1]Department of Dermatology and Venereology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

出　　处：《Chinese Medical Journal》2017年第14期1747-1748,共2页中华医学杂志（英文版）

基　　金：This study was supported by a grant from the Beijing Natural Science Foundation （No. 7163216）.

摘　　要：Porokeratosis （PK）,first described in 1983,is a chronic parakeratotic skin disorder.Clinical types include porokeratosis of Mibelli （PM）,disseminated superficial PK,disseminated superficial actinic porokeratosis （DSAP）,facial PK,and ptychotropica porokeratosis （PP）.Dermoscopic images of PK show an obvious annular margin with scales and an atrophied center.[1] Wood＇s lamp pictures of PK present a diamond necklace-like structure.[2]Gene mutations in mevalonate pathway enzymes,such as mevalonate kinase （MVK）,phosphomevalonate kinase （PMVK）,mevalonate decarboxylase （MVD）,and famesyl diphosphate synthase （FDPS）,may be involved in the pathogenesis of PK.[3,4] In the present study,five sporadic patients with PK were recruited.Dermoscopic features were investigated,and genetic testing was conducted.Porokeratosis （PK）,first described in 1983,is a chronic parakeratotic skin disorder.Clinical types include porokeratosis of Mibelli （PM）,disseminated superficial PK,disseminated superficial actinic porokeratosis （DSAP）,facial PK,and ptychotropica porokeratosis （PP）.Dermoscopic images of PK show an obvious annular margin with scales and an atrophied center.[1] Wood＇s lamp pictures of PK present a diamond necklace-like structure.[2]Gene mutations in mevalonate pathway enzymes,such as mevalonate kinase （MVK）,phosphomevalonate kinase （PMVK）,mevalonate decarboxylase （MVD）,and famesyl diphosphate synthase （FDPS）,may be involved in the pathogenesis of PK.[3,4] In the present study,five sporadic patients with PK were recruited.Dermoscopic features were investigated,and genetic testing was conducted.

关 键 词：DERMOSCOPY MUTATION POROKERATOSIS 

分 类 号：S858.292[农业科学—临床兽医学] Q25[农业科学—兽医学]