针灸联合氟西汀对急性脑梗死伴抑郁患者神经功能、负性情绪及免疫功能的影响  

Acupuncture Combined with Fluoxetine in the Treatment of Acute Cerebral Infarction Accompanied with Depression:Effect on Neurologic Function Recovery,Negative Emotions and Immune Function

作　　者：陈杰[1] 田慧军[2] CHEN Jie TIAN Hui-jun(Daxing Psychiatric Hospital, Beifing 102600, China The 309th Hospital of Chinese People＇s Liberation Army, Belling 100091, China)

机构地区：[1]北京市大兴区精神病医院,北京102600 [2]解放军309医院,北京100091

出　　处：《针灸临床杂志》2017年第7期32-35,共4页Journal of Clinical Acupuncture and Moxibustion

摘　　要：目的:观察针灸联合氟西汀对急性脑梗死(ACI)伴抑郁患者神经功能恢复、负性情绪以及免疫功能的影响。方法:选取56例ACI伴抑郁患者,按入院顺序随机分为康复组(n=28)和对照组(n=28),两组均给予常规药物治疗,对照组给予常规康复治疗,康复组进行针灸联合氟西汀治疗。治疗4周后,比较两组NIHSS评分、Barthel指数(Barthel index,BI)评分及Fugl-Meyer运动功能评分(FMA)。根据SAS、SDS评分量表评价治疗前后患者焦虑和抑郁情绪,并检测免疫功能指标的变化。结果:两组治疗后NIHSS评分较治疗前明显降低(P<0.01或0.05),且治疗后康复组NIHSS评分明显更低于对照组(均P<0.05);两组BI及FMA评分均较治疗前明显提高(P<0.01或0.05),且康复组评分明显更高于对照组(均P<0.05)。治疗后康复组患者的SAS及SDS评分均显著低于对照组(均P<0.05);治疗后康复组患者CD4^+、CD8^+、CD4^+/CD8^+较治疗前有显著性差异(均P<0.01),且康复组较对照组有显著性差异(P<0.05或0.01)。结论:针灸联合氟西汀治疗能有效改善ACI患者神经功能及负性情绪,提高患者的生活质量及免疫功能。Objective：To observe the effects of acupuncture combined with Fluoxetine in the treatment of acute cerebral infarction（ACI） accompanied with depression,in terms of neurologic function recovery,negative emotions,and immune function.Methods：56 ACI patients were randomly divided into the rehabilitation group（n =28） and the control group（n = 28）.Both groups were treated with routine medication,in which the control group was also intervened with conventional rehabilitation measures,and the rehabilitation group was internved with acupuncture combined with Fluoxetine.NIHSS score,Barthel index score,and FMA score were compared between the two groups after four-week treatment.SAS and SDS were used to assess the anxiety and depression of the patients,and immune function indicators were detected before treatment and after four-week treatment in both groups.Results：NIHSS score after treatment was lower than that before treatment in the two groups（P〈0.01,P〈0.05）,and it was much lower in the rehabilitation group than that in the control group（P〈0.05）;the scores of BI and FMA were significantly higher after treatment than those before treatment in both groups（P〈0.01,P〈0.05）,also,the rehabilitation group was superior to the control group（P〈0.05）.Scores of SAS and SDS of the rehabilitation group were significantly lower than those of the control group（P〈0.05）;After treatment,there were significant differences in terms of CD4^＋,CD8^＋,and CD4^＋/CD8^＋ compared to those before treatment（P〈0.01）,which were also statistically significant compared to those of the control group（P〈0.01,P〈0.05）.Conclusion：Acupuncture combined with Fluoxetine can effectively improve neurologic function;negative emotions;life quality;and immune function of the patients with ACI.

关 键 词：急性脑梗死 针刺疗法 氟西汀 负性情绪 免疫功能 

分 类 号：R246.6[医药卫生—针灸推拿学]