电针结合运动康复训练干预兔膝骨关节损伤的抗炎、抗氧化作用  

Interventions of Electro-acupuncture Combined with Rehabilitation Training for Knee Joint Injury in Rabbits:Research of Anti-inflammatory and Anti-oxidant Effect

作　　者：侯建鹏[1] 何劲鹏[2] 李敬孝[1] 刘鹏[1] 朱路文[1] 高俊虎[1] 关吉臣[3] 王博仑 刘建伟[1] 张燕丽[1] HOU Jian - peng HE Jin - peng LI Jing - xiao LIU Peng ZHU Lu - wen GAO Jun - huj GUAN Ji -chen WANG Bo -lun LIU Jian -wei ZHANG Yah -li(Heilongfiang University of Chinese Medicine, Harbin 150040, China Northeast Normal University, Changchun 130024, China Harbin Normal University, Harbin 150020, China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]东北师范大学,吉林长春130024 [3]哈尔滨师范大学,黑龙江哈尔滨150020

出　　处：《针灸临床杂志》2017年第7期64-67,共4页Journal of Clinical Acupuncture and Moxibustion

基　　金：黑龙江省青年科学基金项目;编号:051496

摘　　要：目的:探讨电针结合运动康复训练干预兔膝骨关节损伤模型抗炎、抗氧化作用。方法:将24只新西兰白兔随机分为空白对照组、模型组、阳性药组和针康组,每组各6只。模型组、阳性药组、针康组均于麻醉后,在无菌条件下进行兔膝关节全层关节软骨损伤手术制备模型,空白对照组不给予任何处理。阳性药组给予布洛芬灌胃给药,针康组给予电针结合康复训练。4周后,观测电针结合运动康复训练对兔膝骨关节损伤模型关节液IL-1α、IL-6、NO含量、SOD活性、MDA含量的影响。结果:与空白对照组比较,模型组兔关节液IL-1α、IL-6、NO、MDA含量均明显升高,SOD活性明显降低,差异极显著(P<0.01)。与模型组比较,阳性药组、针康组兔关节液IL-1α、IL-6、NO、MDA含量均明显降低,SOD活性明显升高,差异具有统计学意义(P<0.05或P<0.01)。结论:电针结合运动康复训练可明显降低兔膝骨关节损伤模型关节液IL-1α、IL-6、NO、MDA含量、升高SOD活性,说明其干预膝骨关节损伤模型具有较好的抗炎、抗氧化作用。Objective：To explore the anti-inflammatory and anti-oxidant effects of electro-acupuncture combined with rehabilitation training in rabbit models with knee joint injury.Methods：24 New Zealand white rabbits were randomly divided into the blank control group（group A）,the model group（group B）,the medication group（group C）,and the electro-acupuncture combined with rehabilitation training group（group D）,with six rabbits in each group.Articular cartilage injury operation was applied to establish models under aseptic conditions after anesthesia;Ibuprofen was orally administrated in group C,and electro-acupuncture combined with rehabilitation training was applied in group D.Contents of IL-α,IL-6,NO and MDA,and SOD activity in knee joint fluid were tested after four weeks.Results：The contents of IL-α,IL-6,NO,and MDA were significant increased,and SOD activity was distinctively decreased in group B compared to group A（P〈0.01）.The contents of IL-α,IL-6,NO,and MDA were significant decreased,and SOD activity was distinctively increased after intervention compared to group B（P〈0.05,P〈0.01）.Conclusion：The therapy of electro-acupuncture combined with rehabilitation training could obviously reduce IL-α,IL-6,NO,MDA,and increase SOD activity in keen joint fluid in rabbit models,which showed good anti-inflammatory and anti-oxidant effects.

关 键 词：膝骨关节损伤 电针 运动康复训练 

分 类 号：R246.2[医药卫生—针灸推拿学]