中医药调控肝再生的基础与临床研究  

Basic and Clinical Research of Traditional Chinese Medicine Regulatingand Controlling Liver Regeneration

作　　者：李瀚旻[1] 

机构地区：[1]湖北省中医院(湖北中医药大学附属医院,湖北省中医药研究院)肝病研究所,国家中医药科研细胞分子生物学三级实验室,国家中医药管理局慢性肝病肝肾论治重点研究室,国家中医(肝病)临床研究基地(湖北),湖北武汉430060

出　　处：《中华中医药学刊》2017年第8期1927-1931,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81373513;90709041;30672590;30271562;30371787;81102531;81274147;81573815;81603484);国家重大基础研究计划(973计划)项目(2002CCC00300);国家中医临床研究基地(湖北)重点病种研究项目(JDZX2012054;JDZX2015172);湖北省自然科学基金重点项目(2011CDB463);武汉市科技局科技攻关武汉市重大科技产业化专项项目(201260523199)

摘　　要：中医药调控肝再生是提升中医/中西医结合防治肝脏病证及其相关病证的能力和水平的重要途径与方法。"生机学说"、"肝主生发"等中医药理论的继承创新是中医药调控肝再生的理论基础,"髓生肝"的生理机制、"髓失生肝"的病理机制及"补肾生髓成肝"的疗效机制是中医药调控肝再生的生物学基础,"补肾生髓成肝"治疗肝脏病证的循证医学证据是临床推广应用的科学依据。Regulation of liver regeneration by traditional Chinese medicine（TCM） is an important way to improve the ability and level of TCM or combination of traditional Chinese and Western medicine in the prevention and treatment of liver disease and its related diseases.The inheritance and innovation of the theory of ＂vitality theory＂ and ＂the liver governing growth＂ is the theoretical basis of regulating the liver regeneration.The physiological mechanism of ＂marrow stem cells differentiating into liver cells＂,the pathological mechanism of ＂marrow stem cells failing to differentiate into liver cells＂and the effect mechanism of ＂tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment＂,which are the biological basis of the regulation of liver regeneration by TCM.The evidence of evidence-based medicine for the treatment of liver diseases with ＂tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment＂is a scientific basis of clinical application.

关 键 词：肝再生 肝硬化 肝衰竭 肝癌 中医药 

分 类 号：R256.4[医药卫生—中医内科学]