金华地区9种呼吸道病原体IgM抗体检测结果分析  

Analysis of the detection results of 9 pathogens antibodies causing respiratory tract infections in Jinhua

作　　者：王金华[1] 范希景 项曦[1] 浮苗[1] 

机构地区：[1]金华市中心医院,浙江金华321000

出　　处：《中国卫生检验杂志》2017年第14期2020-2022,2025,共4页Chinese Journal of Health Laboratory Technology

基　　金：金华市科学技术局公益类项目(2017-4-005)

摘　　要：目的分析金华地区9种呼吸道病原体的IgM抗体检测结果及流行情况。方法收集2016年1月-12月门诊与住院的呼吸道感染患者3 224例,应用间接免疫荧光法检测9种病原体IgM抗体:嗜肺军团菌(LP)、肺炎支原体(MP)、立克次体(COX)、肺炎衣原体(CP)、腺病毒(ADV)、呼吸道合胞病毒(RSV)、甲型流感病毒(INFA)和乙型流感病毒(INFB)、副流感病毒(PIV)。结果检测血清IgM阳性610例,总阳性率为18.92%。MP阳性率最高,为12.38%;其次为INFB,阳性率为4.09%;单一感染536例(87.87%),混合感染74例(12.13%)。单一感染以MP为主,混合感染以MP+INFB模式最多。女性IgM阳性检出率高于男性,差异有统计学意义(P<0.05);4岁~17岁为高发人群,>50岁的感染率低于其他人群;IgM总阳性率、MP阳性率在春季最高,而INFB阳性率在秋季最低。结论 MP和INFB是引起本院呼吸道感染的最重要的病原体;应针对不同人群不同季节病原体的流行情况,做好防范工作。Objective To analyze the detection results and epidemiologic characteristics of IgM of 9 respiratory tract pathogens in Jinhua. Methods The serum specimens were collected from 3 224 hospitalized patients with respiratory infection from January to December of 2016,and tested by indirect immunofluorescence assay for IgMs of 9 pathogens including Legionella pneumophila serogroup（ LPl）,Mycoplasma pneumonia（ MP）,Coxiella burnetii（ COX）,Chlamydia pneumonia（ CP）,Adenovirus（ ADV）,Respiratory syncytial viruses（ RSV）,Influenza A（ INFA）,Influenza B（ INFB） and Parainfluenza 1,2 and 3（ PIVs）.Results There were 610 IgM positive cases with the total positive rate of 18. 92%. The highest detection rate of the pathogens were positive MP（ 12. 38%）,followed by INFB（ 4. 09%）. Among the positive cases,536 cases（ 87. 87%） were mono-infections and 74 case（ 12. 13%） were co-infections. Among the mono-infections,MP was the leading causative agent,and MP＋ INFB was the most frequent pathogens combination in co-infections. The detection rate of positive IgMs in female patients were higher than that in male patients,with the difference statistically significant（ P〈0. 05）. The most frequent ages of patients with respiratory tract infection were in 4-17 years,and the infection rate of people 50 years old was lower than other age groups. The overall positive rates of IgM and MP in spring were the highest,but that of INFB in autumn was the lowest. Conclusion MP and INFB are the most predominant pathogens causing respiratory tract infections in our hospital. It is necessary to make protection well done so as to prevent the prevalence and spread of the pathogens in peak seasons.

关 键 词：呼吸道感染 病原体 间接免疫荧光法 肺炎支原体 

分 类 号：R446.6[医药卫生—诊断学]