老年冠心病合并牙周炎患者胃饥饿素/肥胖抑制素比值变化及临床意义  

The change and clinical significance of Ghrelin/obestatin in elderly patients with coronary heart disease complicated with periodontitis

作　　者：袁春儿 黄伟萍[2] 王世俊[2] 

机构地区：[1]余姚市第二人民医院,浙江余姚315400 [2]余姚市人民医院,浙江余姚315400

出　　处：《中国卫生检验杂志》2017年第14期2053-2055,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨牙周炎对老年冠心病患者胃饥饿素(Ghrelin)/肥胖抑制素(obestatin)比值及冠状动脉病变程度影响。方法收集冠心病患者138例作为研究对象,根据是否合并牙周炎及严重程度分为冠心病合并中重度牙周炎组(n=38)、冠心病合并轻度牙周炎组(n=40)、单纯冠心病组(n=60),选择同期健康体检者50例作为对照组。采用ELISA法测定血清Ghrelin、obestatin水平。根据冠脉造影结果采用Gensini积分评估冠脉病变程度。结果冠心病合并牙周炎组、单纯冠心病组患者的Ghrelin/obestatin比值显著低于对照组;冠心病合并牙周炎组患者的Gensini积分明显高于单纯冠心病组,差异均有统计学意义(P<0.05)。冠心病合并牙周炎组患者的Ghrelin/obestatin比值与Gensini积分呈负相关(r=-0.56,P<0.05)。结论老年冠心病合并牙周炎患者的Ghrelin/obestatin比值及牙周炎严重程度与冠状动脉病变程度密切相关。Objective To investigate the effect of periodontitis on the ratio of Ghrelin/obestatin and the severity of coronary artery disease in elderly patients with coronary heart disease. Methods 138 cases of coronary heart disease patients were collected as research subjects,according to whether complicated with periodontitis and the severity of periodontitis,which were divided into coronary heart disease complicated with moderate to severe periodontitis group（ n = 38）,coronary heart disease complicated with mild periodontitis group（ n = 40）,coronary heart disease alone group（ n = 60）,and at the same period 50 cases of healthy volunteers were selected as the control group. Enzyme-linked immunosorbent assay（ ELISA） was used to determine serum Ghrelin and obestatin levels. Gensini score was used to evaluate the extent of coronary lesions according to the results of coronary angiography. Results The Ghrelin/obestatin ratio of coronary heart disease complicated with periodontitis group and simple coronary heart disease group were significantly lower than the control group; the Gensini scores of coronary heart disease complicated with periodontitis group were significantly higher than simple coronary heart disease group,and the differences were both statistically significant（ P〈0. 05）. The Ghrelin/obestatin ratio of patients with coronary heart disease complicated with periodontitis was negatively correlated with Gensini score（ r =-0. 56,P〈0. 05）. Conclusion Ghrelin/obestatin ratio and the severity of periodontitis are closely related to the degree of coronary artery disease in elderly patients with coronary heart disease complicated with periodontitis.

关 键 词：老年冠心病 牙周炎 胃饥饿素/肥胖抑制素比值 冠状动脉病变程度 

分 类 号：R541.4[医药卫生—心血管疾病]