上气道手术对阻塞性睡眠呼吸暂停低通气综合征患者颈动脉血管弹性影响的研究  

A clinical study on the effect of upper airway surgery on carotid elasticity in obstructive sleep apnea hypopnea syndrome patients

作　　者：占小俊[1] 李丽[2] 姚淋尹[1] 孙智甫 葛晓辉[1] 魏永祥[1] 

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所耳鼻咽喉头颈外科,100029 [2]首都医科大学附属北京朝阳医院耳鼻咽喉头颈外科

出　　处：《心肺血管病杂志》2017年第5期356-359,共4页Journal of Cardiovascular and Pulmonary Diseases

基　　金：北京市医院管理局"登峰"计划专项(DFL20150602);国家国际科技合作专项(2015DFA30160)

摘　　要：目的:观察上气道手术是否改善阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者颈动脉血管壁弹性。方法:在手术前和术后半年收集137例行上气道手术OSAHS患者的凝血、血脂和部分患者颈动脉内中膜厚度(CIMT)和动脉血管回声(ET)数据,进行分析比较。结果:术后OSAHS患者颈动脉血管硬度、弹性系数减小,血清凝血酶原时间(PT)、凝血酶时间(TT)延长,纤维蛋白原(FIB)、脂蛋白(a)(LPa)减少。其它各项参数无显著变化。结论:上气道手术术后OSAHS患者颈动脉血管壁弹性等动脉硬化相关指标有所改善,可能对心血管系统有保护性作用。Objective ：To observe whether upper airway surgery can improve carotid artery wall elastic- ity in patients with obstructive sleep apnea hypopnea syndrome （OSAHS）. Methods：A total of 137 patients who underwent upper airway surgery were studied. Before and after surgery the blood coagulation function, blood lipid parameters, carotid intima-media thickness （CIMT） and echo technique （ET） parameters of these OSAHS patients were checked. Analyzed and compared of the improvements of these parameters in OSAHS pa- tients. Results： After the upper airway surgery, PT （prothrombin time） and APTI＇（ activated partial thrombo- plastin time） he prolonged in patients with OSAHS. LP（a）, β and Ep were significantly improved, other parameters did not change significantly. Conclusion：Upper airway surgery can improve blood coagulation function, blood lipid parameters and echo technique parameters in OSAHS patients, which may have potential protective effects on cardiovascular system.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 上气道手术 动脉硬化 

分 类 号：R56[医药卫生—呼吸系统]