山楂消脂胶囊对高脂血症小鼠的降脂作用  

The Hypolipidemic Effect of Shanzhaxiaozhi Capsule on Hyperlipemia Mice

作　　者：李影雄[1] 叶桂样[2] 毛荣军[3] 刘继洪[4] 张常青[5] 雷凯君[1] 

机构地区：[1]佛山市中医院药剂科,广东佛山528000 [2]佛山市中医院检验科,广东佛山528000 [3]佛山市中医院病理科,广东佛山528000 [4]佛山市中医院治未病中心,广东佛山528000 [5]佛山科学技术学院医学院药理教研室,广东佛山528000

出　　处：《今日药学》2017年第7期479-482,共4页Pharmacy Today

摘　　要：目的探讨山楂消脂胶囊对高脂血症模型小鼠的降脂作用。方法高脂饲养建立高脂血症模型小鼠,随机分成6组,即空白对照组、模型组、阳性药(辛伐他汀)治疗组、山楂消脂胶囊高、中、低剂量治疗组。检测血清中的胆固醇及甘油三酯水平,观察小鼠肝脏的组织形态和脂肪沉积状况。结果与空白对照组比较,模型组血清中胆固醇和甘油三酯浓度均显著上升,病理切片显示其肝脏中含有较多脂肪组织,各山楂消脂胶囊治疗组均有不同程度的改善。结论山楂消脂胶囊具有良好的降血脂作用。OBJECTIVE To investigate the hypolipidemic effect of Shanzhaxiaozhi Capsule on hyperlipemia model mice.METHODS Hyperlipemia model mice was established by high-fat diet. All mice were divided into six groups： blank group,hyperlipemia group,positive group（ simvastatin treatment）,three Shanzhaxiaozhi Capsule treatment groups（ high,medium,low concentration）. The serum cholesterol and triglyceride were detected and the livers of mice were also histologically observed. RESULTS The levels of serum cholesterol and triglyceride in hyperlipemia group were higher than blank group. More fatty areas in livers were observed in hyperlipemia group. All the three concentration of Shanzhaxiaozhi Capsule treatment could ameliorate this status.CONCLUSION Shanzhaxiaozhi Capsule has a good hypolipidemic effect.

关 键 词：山楂消脂胶囊 高脂血症 模型小鼠 降脂作用 

分 类 号：R285.5[医药卫生—中药学]