两种阿司匹林减量方式用于川崎病的疗效观察  

Observation on Efficacy of Two Kinds of Decrement of Aspirin in Treatment of Kawasaki Disease

作　　者：许柏华[1] 杨薇斯[1] 刘清彪[1] 胡婷[1] 

机构地区：[1]东莞东华医院儿二科,广东东莞523110

出　　处：《中国医院用药评价与分析》2017年第7期921-923,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨两种阿司匹林减量方式用于川崎病的疗效。方法:选取2014年1月—2016年1月东莞东华医院收治的川崎病患儿84例作为研究对象,以随机数字表法分为A组和B组,每组42例。所有患儿均给予阿司匹林联合静注人免疫球蛋白(p H4)治疗,A组患儿于退热3~5 d后逐渐减少阿司匹林剂量,2周后减至3~5 mg;B组患儿于退热3~5 d后直接减少阿司匹林剂量至3~5 mg。观察两组患儿白细胞计数、血小板计数、红细胞沉降率、C反应蛋白水平及天门冬氨酸氨基转移酶、丙氨酸氨基转移酶等肝功能指标水平,比较两组患儿再次发热率及静注人免疫球蛋白(p H4)再次应用率。结果:治疗后,两组患儿白细胞计数、血小板计数、红细胞沉降率、C反应蛋白及天门冬氨酸氨基转移酶、丙氨酸氨基转移酶水平明显低于本组治疗前,差异均有统计学意义(P<0.05),但两组间的差异无统计学意义(P>0.05);A组患儿再次发热率和静注人免疫球蛋白(p H4)再次应用率分别为2.38%(1/42)、4.76%(2/42),明显低于B组的14.29%(6/42)、21.43%(9/42),差异均有统计学意义(P<0.05)。结论:两种阿司匹林减量方式均可缓解川崎病的临床症状,但逐渐减少阿司匹林剂量能有效降低患儿再发热率和静注人免疫球蛋白(p H4)的再次应用率,有助于患儿早日康复。OBJECTIVE： To probe into the efficacy of two kinds of decrement of aspirin in treatment of Kawasaki disease. METHODS： 84 children with Kawasaki disease admitted into Dongguan Donghua Hospital from Jan. 2014 to Jan. 2016 were selected to be divided into group A and group B via the random number table,with 42 cases in each.All children were given aspirin combined with Human Immunoglobulin（ p H4） for Intravenous Injection. For children in group A,the dose of aspirin was reduced at 3-5 d after abatement of fever,and the dose was directly reduced to 3-5mg after 2 weeks; while children in group B received the dose directly reduced to 3-5 mg at 3-5 d after abatement of fever. The numeration of leukocyte,platelet content,erythrocyte sedimentation rate,high sensitive C-reactive protein,aspartate aminotransferase and alanine aminotransferase of two groups were observed. The rate of fever and application rate of Human Immunoglobulin（ p H4） for Intravenous Injection again of two groups were compared. RESULTS： After treatment,the numeration of leukocyte,platelet content,erythrocyte sedimentation rate,high sensitive C-reactive protein,aspartate aminotransferase and alanine aminotransferase of two groups decreased significantly compared with before treatment,with statistically significant difference（ P 〈0. 05）,but there was no statistically significant difference between two groups（ P〉 0. 05）. The rate of fever and application rate of Human Immunoglobulin（ p H4） for Intravenous Injection again of group A were respectively 2. 38%（ 1/42）,4. 76%（ 2/42）,significantly lower than those of group B [14. 29%（ 6/42）,21. 43%（ 9/42） ], with statistically significant difference（ P 0. 05）.CONCLUSIONS： Two kinds of decrement of aspirin can effectively alleviate the clinical symptoms of patients with Kawasaki disease. Gradually reducing the dose of aspirin can effectively reduce the rate of fever and application rate of Human Immunoglobulin（ p H4） for Intravenous Injection again,which is

关 键 词：川崎病 静注人免疫球蛋白(p H4) 阿司匹林 疗效 

分 类 号：R971.1[医药卫生—药品]