芩香清解口服液的急性毒性和长期毒性研究  

Study on Acute and Long-term Toxicity of Qinxiangqingjie Oral Solution

作　　者：黄娟萍 和芳[2] 白音夫 顾凯 朱明 黄夏梦 邓湘俊 王显著 

机构地区：[1]广州一品红制药有限公司研发中心,广东广州510765 [2]北京创立科创医药技术开发有限公司研发部,北京100029 [3]内蒙古中蒙医研究所药理室,内蒙古呼和浩特010020

出　　处：《中国医院用药评价与分析》2017年第7期934-937,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨芩香清解口服液对小鼠的急性毒性和对大鼠的长期毒性。方法:(1)采用最大给药剂量测定法进行小鼠急性毒性试验。(2)选取大鼠80只进行长期毒性试验,随机分为低、中、高剂量组和对照组,每组20只。于每日上午10点左右给药,低、中、高剂量组大鼠分别给予芩香清解稠膏40、60、80 g/kg,对照组大鼠给予相同体积的蒸馏水,连续灌胃给药4周,停药2周进行恢复性观察。观察大鼠体征、血液分析、脏器系数、肝肾功能及组织切片。结果:急性毒性试验中,小鼠给药后活动减少,未见其他症状。长期毒性试验中,大鼠体征、血液分析、脏器系数、肝肾功能及组织切片均未见明显改变。结论:芩香清解口服液在本研究条件下未发现急性毒性和长期毒性反应,提示该药毒性小,安全性高。OBJECTIVE： To probe into the effects of Qinxiangqingjie oral solution on acute toxicity in mice and longterm toxicity in rats. METHODS：（ 1） Maximum dosimetry was adopted to conduct the acute toxicity test.（ 2） 80 rats extracted for the long-term toxicity test were randomly divided into low,medium and high dose group and control group,with 20 cases in each. Drugs were given at 10： 00 am everyday,low,medium and high dose group were respectively treated with Qinxiangqingjie oral solution of 40 g/kg,60 g/kg and 80 g/kg,yet the control group received the same volume of distilled water; continuous gastric infusion were given for 4 weeks,with drug withdrawal for 2 weeks. Rats＇ signs,blood analysis,organ coefficient,liver,renal function and tissue slice were observed. RESULTS： During the acute toxicity test,the mice decreased the activity after administration,yet there were no other symptoms. During the long-term toxicity test,there was no significant changes in rats＇ signs,blood analysis,organ coefficient,liver,renal function and tissue slice. CONCLUSIONS： Under this experiment condition,there are no acute and long-term toxicity fund in Qinxiangqingjie oral solution,which indicates that Qinxiangqingjie oral solution is safe and reliable.

关 键 词：芩香清解口服液 急性毒性试验 长期毒性试验 

分 类 号：R99[医药卫生—毒理学]