2012—2016年无锡市第三人民医院住院患者抗菌药物使用强度分析  

Analysis on Antibiotics Use Density in Inpatients of the Third People's Hospital of Wuxi During 2012-2016

作　　者：刘言香 李霞[1] 赵懿清[1] 高秋芳[1] 

机构地区：[1]无锡市第三人民医院药学部,江苏无锡214041

出　　处：《中国医院用药评价与分析》2017年第7期947-949,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:了解无锡市第三人民医院(以下简称"我院")抗菌药物使用情况,为指导临床合理应用抗菌药物提供参考依据。方法:收集2012—2016年我院抗菌药物使用记录,采用Excel 2003软件进行统计,以限定日剂量(defined daily dose,DDD)作为用药频度分析的单位,计算抗菌药物使用强度(antibiotics use density,AUD)并进行分析。结果:2012—2016年我院AUD总体呈下降趋势;AUD排序居前3位的抗菌药物为第1代头孢菌素、硝基咪唑类和第3代头孢菌素;AUD排序居前10位的药品均属于β-内酰胺类、氟喹诺酮类、硝基咪唑类和氨基糖苷类抗菌药物,绝大多数为注射剂;5年来,我院AUD平均值[69.19 DDDs/(100人·d)]低于国内平均水平[80.1 DDDs/(100人·d)],但与抗菌药物临床应用整治方案的目标[40 DDDs/(100人·d)]还有很长的距离。结论:我院合理应用抗菌药物的措施落实、有效,但仍存在用药过度、用药集中、用药级别偏高、药物滥用等问题,应进一步细化管理措施,建立完善、长效机制,促进合理用药,避免AUD过度增长。OBJECTIVE： To investigate the use status of antibiotics in the Third People＇s Hospital of Wuxi（ hereinafter referred to as ＂our hospital＂）,so as to provide reference for the rational clinical use of antibiotics.METHODS： Use data of antibiotics in our hospital during 2012-2016 were collected,Excel 2003 software was adopted,defined daily dose（ DDD） was used as the unit,antibiotics use density（ AUD） of antibiotics was calculated and analyzed.RESULTS： The AUD of our hospital was in an decreasing tendency during 2012-2016. The top three antibiotics ranked by AUD were respectively the 1st generation of cephalosporins,nitroimidazoles and the 3rd generation of cephalosporins.The top ten drugs ranked by AUD were respectively β-lactam,fluoroquinolones and aminoglycosides,mainly for injections. For five years,the average AUD of our hospital was 69. 19 DDDs/（ 100 people·d）,lower than the domestic average level[80. 1 DDDs/（ 100 people·d） ],yet it was far from target of clinical use of antibiotics[40 DDDs/（ 100 people·d） ]. CONCLUSIONS： The measures for rational use of antibiotics in our hospital are effective,but still exist some problems as excessive medicine,centralized,high level of drugs,abuse and other issues.It is important to further refine management measures and establish improved long-term mechanism to promote rational use of drugs and avoid excessive increase in AUD.

关 键 词：抗菌药物 限定日剂量 使用强度 用药分析 

分 类 号：R978.1[医药卫生—药品]