脊髓继发性损伤的纳米微粒药物治疗研究进展  

Advances in the Nano particle medicine treatment of secondary spinal cord injury

作　　者：张峻[1,2] 季欣然[1] 唐佩福[1] Zhang Jun Ji Xinran TangPeifu(Department of Orthopaedics, Chinese PLA General Hospital, Beijing 100853 Department of Orthopaedics, the Afliliated Hospital of Innermongolia Medical University Huhot Innermongolia, 010010, China)

机构地区：[1]解放军总医院骨科,北京100853 [2]内蒙古医科大学附属医院骨科,内蒙古呼和浩特010010

出　　处：《生物骨科材料与临床研究》2017年第4期63-66,共4页Orthopaedic Biomechanics Materials and Clinical Study

基　　金：北京市科委重大项目(课题编号:D161100002816005)

摘　　要：由于脊髓原始损伤后发生的生物学级联反应继续损伤健康的神经细胞会导致继发性脊髓损伤,因此及时减轻级联反应可能会减小脊髓进一步损伤。但是,药物达到有效治疗的运输效率非常受限制。运用结合纳米微粒提高运输效率,降低副作用已经成为医疗应用的主要探索领域。基于纳米微粒的材料属性,它可以通过运输药物到特定的组织治疗脊髓损伤。将纳米技术融入神经损伤和神经疾病的治疗将会带给脊髓损伤的治疗带来新的视野。The biological cascade occurs after primary spinal cord injury which damaging original healthy nerve cells leads to secondary spinal cord injury, timely relieving cascade may reduce further damage to the spinal cord. However, the efficiency of drug transport to achieve effective treatment is very limited. Using the combination of nanoparticles to improve transport efficiency and reduce the side effects has become the main research field of medical application. Based on the material properties of nanoparticles, it can be transported to a specific tissue for treatment of spinal cord injury. Integrating nanotechnology into nerve injury and nerve disease treatment will bring the treatment of spinal cord injury a new vision.

关 键 词：脊髓损伤 药物治疗 纳米材料[ 

分 类 号：R651.2[医药卫生—外科学]