427株铜绿假单胞菌的临床分布和耐药性分析  

Analysis of clinical distribution and drug resistance fo 427 strains of Pseudomonas aeruginosa

作　　者：刘刚[1] 魏莲花[1] 邹凤梅[1] 杨永清[1] 朱吉超[2] 邵海鑫 陈晓青[3] 李可可[3] Liu Gang Wei Lianhua Zou Fengmei Yang Yongqing Zhu Jichao Shao Haixin Chen Xiaoqing Li Keke(Gansu Provincial Hospital,Lanzhou 730000,China Ningxia Medical University , Yinchuan 750004,China Gansu University Of Chinese Medicine ,Lanzhou 730000,China)

机构地区：[1]甘肃省人民医院,甘肃兰州730000 [2]宁夏医科大学,宁夏银川750004 [3]甘肃中医药大学,甘肃兰州730000

出　　处：《甘肃医药》2017年第7期531-533,共3页Gansu Medical Journal

基　　金：兰州市科技局科研基金资助项目(项目编号:2014-1-4)

摘　　要：目的:了解铜绿假单胞菌在临床标本中的分布及对抗菌药物的耐药特征,为临床合理用药提供依据。方法:收集2013~2014年临床分离的铜绿假单胞菌,K-B法进行药敏检测后WHONET 5.6对结果进行分析。结果:共分离出427株铜绿假单胞菌,主要来自痰液(44.3%)、分泌物(20.1%)和伤口分泌物(14.3%);科室分布主要为呼吸科(23.2%)和烧伤科(14.3%);铜绿假单胞菌对头孢哌酮的耐药率最高(35.9%),阿米卡星的耐药率最低(6.4%),对其他多种抗菌药物的耐药率较低(<30%),对美洛培南和亚胺培南的耐药率为8.0%和11.2%。结论:铜绿假单胞菌对抗菌药物的耐药率较高,应加强其耐药性的监测。Objective：To investigate the distrtion trend and drug resistance ofPseudomonas aeruginosa so as to provide guidance for the reasonable clinical use of antibiotics. Methods：The P.aeruginosa strains isolated from various specimens that were gotten from 2013 to 2014 were coUeted. The drug susceptibility testing of the clinical isolates was performed with the use of disc diffusion method （K-B method）. And the results were analyazod by using the WHONET 5.6 software. Results：A total fo 427 strains of P.aeruginosa were mainly isolated from the sputum （44.3%）, secretions （20.1% ）, and wound secrutions （14.3%）. The distribution of the department was mainly respiratory department and burn department, the propotion was 23.2% and 14.3%. P.aeruginosa was the most resistant to eefoperazone（35.9% ）,followed by aztreonam （33.7%）, the lowest rate of resistance to amikacin （6.4）, low resistance to other antibiotics （〈30%）. The resistance rates to meropenm and imipenem were 8.0% and 11.2%.Conclusions：The drug resistance of the P.aeruginosa strains to the commonly used antibiotics remains high level, we should enhance the monitoring the drug resistance of the P.aeruginosa.

关 键 词：铜绿假单胞菌 药敏试验 临床分布 耐药性分布 

分 类 号：R378.991[医药卫生—病原生物学]