2016年北京市西城区第二剂麻腮风疫苗复种效果监测分析  

Efficacy of a second dose measles-mumps-rubella vaccine in children in Xicheng District, Beijing, China in 2016

作　　者：王青海[1] 张璐[1] 卢渝军 王庆[1] 秦京宁[1] 

机构地区：[1]北京市西城区疾病预防控制中心,100120

出　　处：《中华微生物学和免疫学杂志》2017年第7期557-559,共3页Chinese Journal of Microbiology and Immunology

摘　　要：目的了解北京市西城区6～7岁儿童接种麻腮风疫苗后，麻疹、风疹和流行性腮腺炎成分疫苗的复种效果。方法采集41名北京市西城区6—7岁儿童麻腮风疫苗免疫前和免疫后1个月双份血标本，ELISA法定量检测麻疹、风疹、流行性腮腺炎IgG抗体。结果41名监测对象麻腮风疫苗中麻疹、风疹、流行性腮腺炎成分复种前抗体阳性率分别为95．12％、90．24％和92．68％，抗体滴度分别为（825．88±499．91）IU／ml、（53．83±32．48）IU／ml和（697．83±535．82）IU／ml；复种后抗体阳性率分别为100％、97．56％和100％，抗体滴度分别为（1102．98±356．77）IU／ml、（95．08±26．88）IU／ml和（3383．85±1903．06）IU／ml。复种后较复种前3种抗体阳性率无明显变化（P〉0．05），而抗体滴度均明显升高（P〈0．05）。结论北京市西城区麻腮风疫苗的18月龄和6岁复种成功率较高，有效保护儿童免受麻疹、风疹、流行性腮腺炎的侵袭。Objective To analyze the efficacy of a second dose of measles-mumps-rubella （MMR） vaccine in children aged 6 to 7 years in Xicheng District, Beijing, China in 2016. Methods Ser- um samples were collected in duplicate from 41 children aged 6 to 7 years before and one month after immu- nization with a second dose of MMR vaccine. ELISA was performed to detect IgG antibodies against measles, rubella and mumps in serum samples. Results The positive rates of antibodies against measles, rubella and mumps in the 41 children before immunization with a second dose of MMR vaccine were 95.12%, 90.24% and 92.68% and the antibody titers were （ 825.88 ±499.91 ）, （53.83 ±32.48） and （697.83 ±535.82） IU/ml, respectively. The positive rates of the three antibodies were 100%, 97.56% and 100% after revaccination with MMR vaccine and the antibody titers were （1 102.98±356. 77）, （95.08±26. 88） and （3 383.85±1 903.06） IU/ml. Titers of antibodies against measles, rubella and mumps increased signifi- cantly following revaccination （P〈0.05）, while no significant difference in the positive rates of the antibod- ies was observed before and after revaccination （P〉0.05）. Conclusion The second dose immunization of MMR vaccine achieves a high successful rate in children in Xicheng District of Beijing. It would be an effective immunization strategy to protect children from measles, rubella and mumps.

关 键 词：麻腮风疫苗 免疫成功率 复种效果 

分 类 号：R186[医药卫生—流行病学]