降钙素原在婴幼儿化脓性脑膜炎早期诊断中的意义  

The significance of procalcitonin in early diagnosis of suppurative meningitis in infants

作　　者：范秋霞[1] Fan Qiuxia(The First People＇s Hospital of Shangqiu,Shangqiu 476000,Chin)

机构地区：[1]商丘市第一人民医院,河南商丘476000

出　　处：《中国实用神经疾病杂志》2017年第14期76-78,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨降钙素原在婴幼儿化脓性脑膜炎早期诊断中的意义。方法将我院2014-02—2015-10收治的71例脑膜炎患者根据临床诊断分为化脓性脑膜炎患儿36例(观察B组)和病毒性脑膜炎患儿35例(观察A组),选择同期于我院治疗的非感染性疾病患儿35例为对照组,3组患者均予以血清降钙素原、C反应蛋白、白细胞计数检测,对比3种检测方法的诊断价值。结果 3组降钙素原、C反应蛋白阳性率对比具有显著性差异(P<0.05),其中观察B组降钙素原阳性率、C反应蛋白阳性率明显高于观察A组、对照组(P<0.05);观察B组内,降钙素原检测阳性率明显高于C反应蛋白、白细胞计数(P<0.05);3组降钙素原、C反应蛋白、白细胞计数定量检测结果对比差异有统计学意义(P<0.05),其中观察B组降钙素原、C反应蛋白、白细胞计数均明显高于观察A组、对照组(P<0.05)。结论降钙素原在婴幼儿化脓性脑膜炎早期诊断中的应用价值高,值得推广。Objective To investigate the significance of procalcitonin in the early diagnosis of suppurative meningitis in in- fants. Methods Seventy-one patients with meningitis who were treated in our hospital from February 2014 to October 2015 were divided into 36 cases of purulent meningitis （observation group B） and 35 cases of viral meningitis viral meningitis （observation group A） according to the clinical diagnosis. At the same time,35 children with non-infectious diseases treated in our hospital were selected as the control group. The serum procalcitonin, C-reactive protein and white blood cell count were detected in the three groups,and the diagnostic value of the three methods was compared. Results The positive rates of procalcitonin and C-reactive protein in the three groups were significantly different （P〈0.05）. The positive rate of procalcitonin and the rate of C-reactive pro- tein in the observation group B were significantly higher than those in the group A and the control group （P〈0.05）. The positive rate of procalcitonin was significantly higher than that of C-reactive protein and white blood cell count in the observation group B （P〈 0.05）. The differences in the three groups of children with procalcitonin, C-reactive protein, white blood cell count quantitative test results were statistically significant （P〈0.05）. The levels of procalcitonin,C-reactive protein and white blood cell count in group B were significantly higher than those in group A and control group （P%0.05）. Conclusion Procalcitonin is of high value in early diagnosis of purulent meningitis in infants and children and is worth popularizing.

关 键 词：降钙素原 婴幼儿 化脓性脑膜炎 

分 类 号：R512.3[医药卫生—内科学]